Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Antibodies Inc
GABA-A-R-Alpha5 Monoclonal Antibody (N415/24)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
GABA-A-R-Alpha5 Antibody (75-401) in ICC/IF
Immunolabelling showing alpha-1-/alpha-5-containing GABAA receptors demonstrated synaptic localizations in a primary hippocampal neuronal culture. Distributions of alpha-1 and alpha-5 (Product # 75-401, 1:1000) subunits (A,B) were co-stained with the inhibitory presynaptic marker protein vGat (C). (D) The alpha-1 subunit was mostly synaptically localized, opposing vGat, whereas alpha-5 was distributed at bo... View More
Product Details
75-401
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N415/24
Immunogen
Fusion protein amino acids 368-419 (last cytoplasmic domain before extracellular C-terminus) of human GABA-A-R-Alpha5 (accession number P31644) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
GABRA5 is a part of GABA, a major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: GABA(A) receptor; GABA(A) receptor subunit alpha-5; GABA-A receptor alpha-5 subunit; GABAA receptor alpha5 subunit; GABAAR subunit alpha-5; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 5; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5; gamma-aminobutyric acid A receptor, alpha 5; Gamma-aminobutyric acid receptor subunit alpha-5; ligand-gated ion channel subunit
Gene Aliases: A230018I05Rik; Gabra-5; GABRA5
UniProt ID: (Human) P31644, (Rat) P19969, (Mouse) Q8BHJ7
Entrez Gene ID: (Human) 2558, (Rat) 29707, (Mouse) 110886
behavioral fear response
positive regulation of defense response to virus by host
transport
signal transduction
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
brain development
sensory perception of sound
associative learning
ion transmembrane transport
negative regulation of neuron apoptotic process
inner ear receptor cell development
innervation
cochlea development
mitophagy in response to mitochondrial depolarization
xenophagy
chloride transmembrane transport
regulation of neuron apoptotic process
neuron development
ion transport
chloride transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support