This antibody detected endogenous GABARAP protein in lysates from various tissues. It may cross-react with GABARAPL1 due to the high identity of amino acid sequence.
Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ25768; GABA(A) receptor-associated protein; GABA-A receptor-associated protein; GABARAP a; gamma-aminobutyric acid receptor associated protein; Gamma-aminobutyric acid receptor-associated protein; gamma-aminobutyric acid reseptor associated protein; hypothetical protein; MGC120154; MGC120155; MM46
Gene Aliases: ATG8A; FLC3B; GABARAP; GABARAP-a; HT004; MM46