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Invitrogen
GABARAP Polyclonal Antibody
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Product Details
PA1-4145
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues R(15) S E G E K I R K K Y P D R V P V(31) of human GABARAP.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-4145 detects GABA Receptor Associated Protein in human samples.
PA1-4145 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~14 kDa protein representing GABA Receptor Associated Protein in brain lysate.
The PA1- 4145 immunogen is a synthetic peptide corresponding to residues R(15) S E G E K I R K K Y P D R V P V(31) of human GABARAP.
Target Information
Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; FLJ25768; GABA(A) receptor-associated protein; GABARAP; GABARAP a; Gamma-aminobutyric acid receptor-associated protein; MGC120154; MGC120155; MM46; unnamed protein product
Gene Aliases: ATG8A; FLC3B; GABARAP; GABARAP-a; HT004; MM46
UniProt ID: (Human) O95166
Entrez Gene ID: (Human) 11337
autophagosome assembly
microtubule cytoskeleton organization
mitophagy
protein targeting
autophagy
apoptotic process
cellular response to nitrogen starvation
chemical synaptic transmission
extrinsic apoptotic signaling pathway via death domain receptors
protein transport
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of Rac protein signal transduction
autophagosome maturation
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
positive regulation of protein K48-linked ubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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