PA5-27725 targets GABA B Receptor 1 in WB applications and shows reactivity with Human and mouse samples.
The PA5-27725 immunogen is recombinant fragment corresponding to a region within amino acids 268 and 532 of Human GABA B Receptor 1.
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Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.
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Protein Aliases: bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a); dJ271M21.1.1; dJ271M21.1.2; GABA-B receptor 1; GABA-B receptor, R1 subunit; GABA-B-R1; GABA-BR1; GABA-BR1b receptor; GABAB; GABABR1; GABBR1-3; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid (GABA-B) receptor, 1; Gamma-aminobutyric acid type B receptor subunit 1; GB1; GPRC3A; seven transmembrane helix receptor; subunit 1c
Gene Aliases: bM573K1.1; GABAB1; GABABR1; GABBR1; GABBR1-3; GB1; GPRC3A