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Huabio
GABPA Polyclonal Antibody
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FIGURE: 1 / 1
GABPA Antibody (HA500187) in WB
Western blot analysis of GABPA on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (HA500187, 1:500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:5,000 dilution was used for 1 hour at room temperature. Positive control: Lane 1: A431 cell lysate Lane 2: HeLa cell lysate Lane 3: 293T cell lysate.
Product Details
HA500187
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human GABPA aa 1-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GA binding protein transcription factor alpha subunit 60kDa; GA repeat binding protein alpha; GA-binding protein alpha chain; GA-binding protein alpha-subunit; GABP subunit alpha; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor 2 alpha subunit; Nuclear respiratory factor 2 subunit alpha; Transcription factor E4TF1-60; unnamed protein product
Gene Aliases: E4TF1-60; E4TF1A; GABPA; GABPalpha; NFT2; NRF2; NRF2A; RCH04A07
UniProt ID: (Human) Q06546, (Mouse) Q00422
Entrez Gene ID: (Human) 2551, (Mouse) 14390
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription regulatory region DNA binding
protein heterodimerization activity
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
blastocyst formation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell differentiation
negative regulation of megakaryocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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