Proteintech

GABRA1 Polyclonal Antibody

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GABRA1 Antibody (12410-1-AP) in WB

Mouse brain tissue were subjected to SDS PAGE followed by western blot with (Product # 12410-1-AP) GABRA1 antibody at dilution of 1:2,000 incubated at room temperature for 1.5 hours.

GABRA1 Antibody in Flow Cytometry (Flow)

GABRA1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12410-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 21 publications 21 publications

Immunocytochemistry (ICC/IF)

Assay-dependent

View 4 publications 4 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GABRA1 Fusion Protein Ag3117 (21-280 aa encoded by BC030696)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LTGRSYGQP SLQDELKDNT TVFTRILDRL LDGYDNRLRP GLGERVTEVK TDIFVTSFGP VSDHDMEYTI DVFFRQSWKD ERLKFKGPMT VLRLNNLMAS KIWTPDTFFH NGKKSVAHNM TMPNKLLRIT EDGTLLYTMR LTVRAECPMH LEDFPMDAHA CPLKFGSYAY TRAEVVYEWT REPARSVVVA EDGSRLNQYD LLGQTVDSGI VQSSTGEYVV MTTHFHLKRK IGYFVIQTYL PCIMTVILSQ VSFWLNRESV P (21-280 aa encoded by BC030696)

Target Information

Gamma -aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date aix alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-R sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. Lastly, phosphorylation of beta-subunits of the receptor has been shown to modulate GABAA-R function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis.

eLife

Ichinose S,Susuki Y,Hosoi N,Kaneko R,Ebihara M,Hirai H,Iwasaki H

Mon Jun 05 00:00:00 UTC 2023

Circulating Plasma Exosomal Proteins of Either SHIV-Infected Rhesus Macaque or HIV-Infected Patient Indicates a Link to Neuropathogenesis.

Viruses

Chandra PK,Braun SE,Maity S,Castorena-Gonzalez JA,Kim H,Shaffer JG,Cikic S,Rutkai I,Fan J,Guidry JJ,Worthylake DK,Li C,Abdel-Mageed AB,Busija DW

Tue Mar 21 00:00:00 UTC 2023

Magnify is a universal molecular anchoring strategy for expansion microscopy.

Nature biotechnology

Klimas A,Gallagher BR,Wijesekara P,Fekir S,DiBernardo EF,Cheng Z,Stolz DB,Cambi F,Watkins SC,Brody SL,Horani A,Barth AL,Moore CI,Ren X,Zhao Y

Thu Jun 01 00:00:00 UTC 2023

Amelioration of olfactory dysfunction in a mouse model of Parkinson's disease via enhancing GABAergic signaling.

Cell & bioscience

Liu XY,Wang K,Deng XH,Wei YH,Guo R,Liu SF,Zhu YF,Zhong JJ,Zheng JY,Wang MD,Ye QH,He JQ,Guo KH,Zhu JR,Huang SQ,Chen ZX,Lv CS,Wen L

Sat Jun 03 00:00:00 UTC 2023

Triptolide injection reduces Alzheimer's disease-like pathology in mice.

Synapse (New York, N.Y.)

Mao R,Xu S,Sun G,Yu Y,Zuo Z,Wang Y,Yang K,Zhang Z,Yang W

Mon May 01 00:00:00 UTC 2023

Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation.

Current research in neurobiology

Auta J,Locci A,Guidotti A,Davis JM,Dong H

Wed Dec 21 00:00:00 UTC 2022

MRI Characteristics of Autoimmune Encephalitis With Autoantibodies to GABAA Receptor: A Case Series.

Neurology(R) neuroimmunology & neuroinflammation

Deng B,Cai M,Qiu Y,Liu X,Yu H,Zhang X,Huang H,Zhao X,Yang W,Dong S,Jin L,Chu S,Chen X

Sun May 01 00:00:00 UTC 2022

Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures.

Frontiers in molecular neuroscience

Liu X,Zhang L,Zhang H,Liang X,Zhang B,Tu J,Zhao Y

Sat Jul 16 00:00:00 UTC 2022

KangPiLao decoction modulates cognitive and emotional disorders in rats with central fatigue through the GABA/Glu pathway.

Frontiers in pharmacology

Xu Y,Lian Y,Li J,Zhang Y,Liu Y,Wang X,Ma J,Li F

Tue Sep 20 00:00:00 UTC 2022

The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy.

International journal of molecular sciences

Popek M,Bobula B,Orzeł-Gajowik K,Zielińska M

Wed Jan 19 00:00:00 UTC 2022

Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson's disease.

Molecular therapy. Nucleic acids

Stein CS,McLendon JM,Witmer NH,Boudreau RL

Tue Jun 14 00:00:00 UTC 2022

Rare variants in GABRG2 associated with sleep-related hypermotor epilepsy.

Journal of neurology

Jiang YL,Song CG,Zhou HM,Feng B,Zhao JJ,Liu Y,Man YL,Han J,Liu SB,Jiang W

Thu Sep 01 00:00:00 UTC 2022

Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAA receptor and GABAergic neuron in corresponding nuclei.

Acta biochimica et biophysica Sinica

Jiang J,Jiao Y,Gao P,Yin W,Zhou W,Zhang Y,Liu Y,Wen D,Wang Y,Zhou L,Yu T,Yu W

Wed Jul 28 00:00:00 UTC 2021

Mir-139-5p inhibits glioma cell proliferation and progression by targeting GABRA1.

Journal of translational medicine

Wang L,Liu Y,Yu Z,Gong J,Deng Z,Ren N,Zhong Z,Cai H,Tang Z,Cheng H,Chen S,He Z

Mon May 17 00:00:00 UTC 2021

Autism-Like Behavior in the Offspring of CYP11A1-Overexpressing Pregnant Rats.

Frontiers in neuroscience

Pan T,Jiang C,Cheng J,Xie J,Liu X,Xu W,He G

Fri Nov 03 00:00:00 UTC 2023

Reconstituting neurovascular unit with primary neural stem cells and brain microvascular endothelial cells in three-dimensional matrix.

Brain pathology (Zurich, Switzerland)

Wang H,Yang H,Shi Y,Xiao Y,Yin Y,Jiang B,Ren H,Chen W,Xue Q,Xu X

Wed Sep 01 00:00:00 UTC 2021

Ginsenoside Rg5/Rk1 ameliorated sleep via regulating the GABAergic/serotoninergic signaling pathway in a rodent model.

Food & function

Shao J,Zheng X,Qu L,Zhang H,Yuan H,Hui J,Mi Y,Ma P,Fan D

Wed Feb 26 00:00:00 UTC 2020

PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia.

iScience

Jiang C,Wang Z,Donnelly CR,Wang K,Andriessen AS,Tao X,Matsuda M,Zhao J,Ji RR

Fri Oct 23 00:00:00 UTC 2020

STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.

CNS neuroscience & therapeutics

Yang J,Jiang Q,Yu X,Xu T,Wang Y,Deng J,Liu Y,Chen Y

Sat Aug 01 00:00:00 UTC 2020

STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.

CNS neuroscience & therapeutics

Yang J,Jiang Q,Yu X,Xu T,Wang Y,Deng J,Liu Y,Chen Y

Sat Aug 01 00:00:00 UTC 2020

PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats.

Neurobiology of disease

Mo J,Wang B,Zhu X,Wu X,Liu Y

Tue Jan 01 00:00:00 UTC 2019

PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats.

Neurobiology of disease

Mo J,Wang B,Zhu X,Wu X,Liu Y

Tue Jan 01 00:00:00 UTC 2019

As a Histone Deacetylase Inhibitor, γ-Aminobutyric Acid Upregulates GluR2 Expression: An In Vitro and In Vivo Study.

Molecular nutrition & food research

Xing A,Li X,Jiang C,Chen Y,Wu S,Zhang J,An L

Sun Sep 01 00:00:00 UTC 2019

Transgenic overexpression of furin increases epileptic susceptibility.

Cell death & disease

Yang Y,He M,Tian X,Guo Y,Liu F,Li Y,Zhang H,Lu X,Xu D,Zhou R,Ma Y,Wang W,Chen G,Hu Y,Wang X

Wed Oct 17 00:00:00 UTC 2018

Transgenic overexpression of furin increases epileptic susceptibility.

Cell death & disease

Yang Y,He M,Tian X,Guo Y,Liu F,Li Y,Zhang H,Lu X,Xu D,Zhou R,Ma Y,Wang W,Chen G,Hu Y,Wang X

Wed Oct 17 00:00:00 UTC 2018

c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression.

Acta physiologica (Oxford, England)

Wang R,Zhang W,Dong Z,Qi Y,Hultström M,Zhou X,Lai EY

Wed Feb 01 00:00:00 UTC 2017

c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression.

Acta physiologica (Oxford, England)

Wang R,Zhang W,Dong Z,Qi Y,Hultström M,Zhou X,Lai EY

Wed Feb 01 00:00:00 UTC 2017

c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression.

Acta physiologica (Oxford, England)

Wang R,Zhang W,Dong Z,Qi Y,Hultström M,Zhou X,Lai EY

Wed Feb 01 00:00:00 UTC 2017

c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression.

Acta physiologica (Oxford, England)

Wang R,Zhang W,Dong Z,Qi Y,Hultström M,Zhou X,Lai EY

Wed Feb 01 00:00:00 UTC 2017

The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities.

Frontiers in molecular neuroscience

Zhang Y,Gao B,Zheng F,Lu S,Li Y,Xiong Y,Yang Q,Yang Y,Fu P,Xiao F,Wang X

Thu Oct 01 00:00:00 UTC 2020

The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities.

Frontiers in molecular neuroscience

Zhang Y,Gao B,Zheng F,Lu S,Li Y,Xiong Y,Yang Q,Yang Y,Fu P,Xiao F,Wang X

Thu Oct 01 00:00:00 UTC 2020

Sperm gamma-aminobutyric acid type A receptor delta subunit (GABRD) and its interaction with purinergic P2X₂ receptors in progesterone-induced acrosome reaction and male fertility.

Reproduction, fertility, and development

Xu W,Wang K,Chen Y,Liang XT,Yu MK,Yue H,Tierney ML

Fri Sep 01 00:00:00 UTC 2017

Sperm gamma-aminobutyric acid type A receptor delta subunit (GABRD) and its interaction with purinergic P2X₂ receptors in progesterone-induced acrosome reaction and male fertility.

Reproduction, fertility, and development

Xu W,Wang K,Chen Y,Liang XT,Yu MK,Yue H,Tierney ML

Fri Sep 01 00:00:00 UTC 2017

Sperm gamma-aminobutyric acid type A receptor delta subunit (GABRD) and its interaction with purinergic P2X₂ receptors in progesterone-induced acrosome reaction and male fertility.

Reproduction, fertility, and development

Xu W,Wang K,Chen Y,Liang XT,Yu MK,Yue H,Tierney ML

Fri Sep 01 00:00:00 UTC 2017

Sperm gamma-aminobutyric acid type A receptor delta subunit (GABRD) and its interaction with purinergic P2X₂ receptors in progesterone-induced acrosome reaction and male fertility.

Reproduction, fertility, and development

Xu W,Wang K,Chen Y,Liang XT,Yu MK,Yue H,Tierney ML

Fri Sep 01 00:00:00 UTC 2017

Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension.

Scientific reports

Chen HH,Cheng PW,Ho WY,Lu PJ,Lai CC,Tseng YM,Fang HC,Sun GC,Hsiao M,Liu CP,Tseng CJ

Mon Dec 05 00:00:00 UTC 2016

Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension.

Scientific reports

Chen HH,Cheng PW,Ho WY,Lu PJ,Lai CC,Tseng YM,Fang HC,Sun GC,Hsiao M,Liu CP,Tseng CJ

Mon Dec 05 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1; GABAA alpha 1; GABAAR alpha1; GABAAR subunit alpha-1; GABRA 1; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1; gamma-aminobutyric acid A receptor, alpha 1; Gamma-aminobutyric acid receptor subunit alpha-1

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Gene Aliases: ECA4; EIEE19; EJM; EJM5; Gabra-1; GABRA1

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UniProt ID: (Human) P14867, (Rat) P62813, (Mouse) P62812

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Entrez Gene ID: (Human) 2554, (Rat) 29705, (Mouse) 14394

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Function(s)

GABA-A receptor activity drug binding GABA receptor activity GABA-gated chloride ion channel activity inhibitory extracellular ligand-gated ion channel activity chloride channel activity protein binding benzodiazepine receptor activity ion channel activity extracellular ligand-gated ion channel activity ligand-gated ion channel

Process(es)

transport gamma-aminobutyric acid signaling pathway ion transmembrane transport synaptic transmission, GABAergic cellular response to histamine chloride transmembrane transport chloride transport ion transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GABRA1 Polyclonal Antibody

GABRA1 Antibody (12410-1-AP) in WB

Product Details

12410-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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