This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: KPKKVKDPLI KKNNTYAPTA TSYTPNLARG DPGLATIAKS ATIEPKEVKP E
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Gamma -aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date aix alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-R sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003). Lastly, phosphorylation of beta-subunits of the receptor has been shown to modulate GABAA-R function (Brandon et al., 2003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha 1; ECA4; EJM; EJM5; GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; Gamma-aminobutyric acid receptor subunit alpha-1
Gene Aliases: ECA4; EIEE19; EJM; EJM5; GABRA1
UniProt ID: (Human) P14867
Entrez Gene ID: (Human) 2554