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Invitrogen
GABRA1 Polyclonal Antibody
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FIGURE: 1 / 1
GABRA1 Antibody (PA5-88441) in WB
Western blot analysis of GABRA1 in mouse brain. Samples were incubated with GABRA1 Polyclonal antibody (Product # PA5-88441) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
Product Details
PA5-88441
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 28-251 of human GABRA1 (NP_0007972)
Conjugate
Form
Liquid
Concentration
3.55 mg/mL
Amount
355 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QPSLQDELKD NTTVFTRILD RLLDGYDNRL RPGLGERVTE VKTDIFVTSF GPVSDHDMEY TIDVFFRQSW KDERLKFKGP MTVLRLNNLM ASKIWTPDTF FHNGKKSVAH NMTMPNKLLR ITEDGTLLYT MRLTVRAECP MHLEDFPMDA HACPLKFGSY AYTRAEVVYE WTREPARSVV VAEDGSRLNQ YDLLGQTVDS GIVQSSTGEY VVMTTHFHLK RKIG; Positive Samples: Mouse brain; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Target Information
Gamma -aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date aix alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-R sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. Lastly, phosphorylation of beta-subunits of the receptor has been shown to modulate GABAA-R function.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA(A) receptor subunit alpha-1; GABAA alpha 1; GABAAR alpha1; GABAAR subunit alpha-1; GABRA 1; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1; Gamma-aminobutyric acid receptor subunit alpha-1
Gene Aliases: Gabra-1; Gabra1
UniProt ID: (Mouse) P62812
Entrez Gene ID: (Mouse) 14394
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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