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Invitrogen
GABRB2 Polyclonal Antibody
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Product Details
PA5-102506
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GABRB2(Accession P47870), corresponding to amino acid residues M1-N32.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total GABRB2.
Target Information
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA(A) receptor subunit beta-2; GABAAR subunit beta-2; GABAARbeta2; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2; gamma-aminobutyric acid A receptor beta 2; gamma-aminobutyric acid A receptor, subunit beta 2; Gamma-aminobutyric acid receptor beta 2; gamma-aminobutyric acid receptor beta-2 subunit; Gamma-aminobutyric acid receptor subunit beta-2; gamma-aminobutyric acid receptor, subunit beta 2; gamma-aminobutyric acid type A receptor beta2 subunit; long form; MGC119386; MGC119388; MGC119389; short form; unnamed protein product
Gene Aliases: AI834970; C030002O17Rik; C030021G16Rik; DEE92; Gabrab2; Gabrb-2; GABRB2; GARB2; ICEE2
UniProt ID: (Human) P47870, (Mouse) P63137, (Rat) P63138
Entrez Gene ID: (Human) 2561, (Mouse) 14401, (Rat) 25451
transmembrane signaling receptor activity
GABA-A receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
chloride channel activity
GABA receptor activity
GABA-gated chloride ion channel activity
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
inhibitory extracellular ligand-gated ion channel activity
protein binding
ligand-gated ion channel
ion transport
chloride transport
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
ion transmembrane transport
neuron development
synaptic transmission, GABAergic
regulation of postsynaptic membrane potential
inner ear receptor cell development
innervation
cellular response to histamine
cochlea development
chloride transmembrane transport
inhibitory synapse assembly
transport
signal transduction
sensory perception of sound
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
negative regulation of neuron death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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