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Invitrogen
GABRB2 Polyclonal Antibody
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FIGURE: 1 / 1
GABRB2 Antibody (PA5-95972) in WB
Western blot analysis of GABRB2 in extracts of various cell lines. Samples were incubated with GABRB2 Polyclonal antibody (Product # PA5-95972) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
PA5-95972
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 26-244 of human GABA A Receptor beta 2 (GABA A Receptor beta 2 (GABRB2)) (NP_0008041)
Conjugate
Form
Liquid
Concentration
0.46 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SVNDPSNMSL VKETVDRLLK GYDIRLRPDF GGPPVAVGMN IDIASIDMVS EVNMDYTLTM YFQQAWRDKR LSYNVIPLNL TLDNRVADQL WVPDTYFLND KKSFVHGVTV KNRMIRLHPD GTVLYGLRIT TTAACMMDLR RYPLDEQNCT LEIESYGYTT DDIEFYWRGD DNAVTGVTKI ELPQFSIVDY KLITKKVVFS TGSYPRLSLS FKLKRNIGY; Positive Samples: Mouse liver; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Target Information
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA(A) receptor subunit beta-2; GABAAR subunit beta-2; GABAARbeta2; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2; gamma-aminobutyric acid A receptor beta 2; gamma-aminobutyric acid A receptor, subunit beta 2; gamma-aminobutyric acid receptor beta-2 subunit; Gamma-aminobutyric acid receptor subunit beta-2; MGC119386; MGC119388; MGC119389
Gene Aliases: AI834970; C030002O17Rik; C030021G16Rik; Gabrab2; Gabrb-2; GABRB2
UniProt ID: (Human) P47870, (Mouse) P63137
Entrez Gene ID: (Human) 2561, (Mouse) 14401
transport
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
sensory perception of sound
ion transmembrane transport
negative regulation of neuron apoptotic process
synaptic transmission, GABAergic
inner ear receptor cell development
innervation
cellular response to histamine
cochlea development
chloride transmembrane transport
ion transport
chloride transport
signal transduction
regulation of neuron apoptotic process
neuron development
negative regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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