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Invitrogen
GABRB3 Polyclonal Antibody
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FIGURE: 1 / 4
GABRB3 Antibody (PA5-19060) in IHC (P)
Immunohistochemistry analysis of GABRB3 in human brain, cortex. Samples were incubated with GABRB3 polyclonal antibody (Product # PA5-19060) using a dilution of 2.5 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-19060
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (EKTAKAKNDRSK) corresponding to the internal amino acids of GABRB3 (aa 344-356).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.
Preliminary analysis showed no signal in Western Blot.
Target Information
Gamma-amino butyric acid (GAMA) is a strong inhibitor of neuron transmission and is found throughout the central nervous system. GABA is formed by the decarboxylation of glutamate, resulting in the formation of one of two distinct types; GABA-A or GABA-B.The binding of GABA to GABA-A receptors results in the increase transportation of chlorine ions into the neuron. This influx results in signal transmission repression. Studies have shown that if cell to cell signaling goes unchecked due to a lack of GABA, a system overload can resulting in blackouts, rapid body contractions, seizures and epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GABA(A) receptor subunit beta-3; GABA-alpha receptor beta-2 subunit; GABAA receptor beta-3 subunit; GABAAR subunit beta-3; GABR B3; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid A receptor beta 3; Gamma-aminobutyric acid receptor subunit beta-3; gamma-aminobutyric acid type A receptor beta3 subunit; gamma-aminobutyric acid type A receptor subunit beta 3; MGC9051; unnamed protein product
Gene Aliases: DEE43; ECA5; EIEE43; GABRB3
UniProt ID: (Human) P28472
Entrez Gene ID: (Human) 2562
transmembrane signaling receptor activity
GABA-A receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
chloride channel activity
GABA-gated chloride ion channel activity
identical protein binding
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
ion transport
chloride transport
signal transduction
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
nervous system development
brain development
learning
memory
response to xenobiotic stimulus
reproductive behavior
cerebellum development
ion transmembrane transport
social behavior
exploration behavior
circadian sleep/wake cycle, REM sleep
neuron development
synaptic transmission, GABAergic
palate development
hard palate development
inhibitory postsynaptic potential
inner ear receptor cell development
innervation
motor behavior
cellular response to zinc ion
cellular response to histamine
response to anesthetic
cochlea development
chloride transmembrane transport
inhibitory synapse assembly
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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