GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Ralpha1-6, GABAA R beta1-3, GABAA Rgamma1-3, GABAA Rdelta, GABAA Repsilon, GABAA Rrho1 and GABAA Rrho2. The GABAB family is composed of GABAB R1alpha and GABAB R1beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
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Protein Aliases: GABA A receptor delta; GABA(A) receptor subunit delta; GABA(A) receptor, delta; GABA-A receptor delta-subunit; GABA-A receptor, delta polypeptide; GABAA receptor delta; GABAA receptor delta subunit; GABRD; gamma-aminobutyric acid A receptor, delta; gamma-aminobutyric acid (GABA) A receptor, delta; gamma-aminobutyric acid (GABA-A) receptor, subunit delta; gamma-aminobutyric acid A receptor, delta; Gamma-aminobutyric acid receptor subunit delta
Gene Aliases: AI853201; EIG10; EJM7; GABAA-RD; GABRD; GEFSP5