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Invitrogen
GABRG2 Polyclonal Antibody
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FIGURE: 1 / 4
GABRG2 Antibody (PA5-23698) in IHC (P)
Immunohistochemistry analysis of GABRG2 in formalin fixed and paraffin embedded human brain tissue. Samples were incubated with GABRG2 polyclonal antibody (Product # PA5-23698) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-23698
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 198-224 amino acids from the central region of human GABRG2
Conjugate
Form
Liquid
Concentration
2 mg/mL
Amount
800 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine and rat based on sequence homology.
Target Information
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GABA(A) receptor subunit gamma-2; GABA(A) receptor, gamma 2; GABAAR subunit gamma-2; GABRA2; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, gamma 2; Gamma-aminobutyric acid receptor subunit gamma-2; gamma-aminobutyric acid type A receptor gamma2 subunit; unnamed protein product
Gene Aliases: CAE2; DEE74; ECA2; EIEE74; FEB8; GABAA-R; Gabrg-2; GABRG2; gamma2; GEFSP3
UniProt ID: (Human) P18507, (Mouse) P22723
Entrez Gene ID: (Human) 2566, (Mouse) 14406
transmembrane signaling receptor activity
GABA-A receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
chloride channel activity
protein binding
benzodiazepine receptor activity
GABA-gated chloride ion channel activity
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
GABA receptor activity
ligand-gated ion channel
ion transport
chloride transport
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
post-embryonic development
adult behavior
ion transmembrane transport
synaptic transmission, GABAergic
regulation of postsynaptic membrane potential
cellular response to histamine
chloride transmembrane transport
inhibitory synapse assembly
transport
signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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