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Proteintech
GABRR1 Polyclonal Antibody
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Product Details
25899-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GABRR1 Fusion Protein Ag23165 (19-78 aa encoded by BC130344)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RMHWPGREV HEMSKKGSRP QRQRREVHED AHKQVSPILR RSPDITKSPL TKSEQLLRID D (19-78 aa encoded by BC130344)
Target Information
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels; however, they are structurally and functionally distinct. GABAC receptors (GABAC Rr) mediate rapid inhibitory neurotransmission in retina. Three human genes, r1 (GABRR1), r2 (GABRR2) and r3 (GABRR3), encode the three polypeptides that comprise this receptor. GABRR1 and GABRR2 are located close together, in a region of chromosome 6q that contains loci for inherited disorders of the eye, but GABRR3 maps to chromosome 3q11-q13.3. The r polypeptide genes, which are thought to share a common ancestor with GABA(A) receptor subunit genes, diverged at an early stage in the evolution of this gene family. The expression of GABAC Rr subunits is not restricted to the retina, but significant expression can also be detected in many other brain regions, especially in those belonging to the visual pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bA135P14.1 (gamma-aminobutyric acid (GABA) receptor, rho 1); GABA(A) receptor subunit rho-1; GABA(A) receptor, rho 1; GABA(C) receptor; GABA(C) rho1; GABAAR subunit rho-1; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, rho-1; gamma-aminobutyric acid (GABA) receptor, rho 1; gamma-aminobutyric acid (GABA-A) receptor, subunit rho 1; gamma-aminobutyric acid (GABA-C) receptor, subunit rho 1; Gamma-aminobutyric acid receptor subunit rho-1; gamma-aminobutyric acid type A receptor rho1 subunit; unnamed protein product
Gene Aliases: GABA-C; GABRR1
UniProt ID: (Human) P24046, (Mouse) P56475
Entrez Gene ID: (Human) 2569, (Mouse) 14408
transmembrane signaling receptor activity
GABA-A receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
chloride channel activity
GABA receptor activity
protein domain specific binding
GABA-gated chloride ion channel activity
identical protein binding
macromolecular complex binding
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
protein homodimerization activity
protein heterodimerization activity
ligand-gated ion channel
ion transport
chloride transport
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
ion transmembrane transport
modulation of synaptic transmission
synaptic transmission, GABAergic
regulation of presynaptic membrane potential
chloride transmembrane transport
transport
signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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