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Proteintech
GADD34 Polyclonal Antibody
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Product Details
10449-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Hamster,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GADD34 Fusion Protein Ag0578 (307-572 aa encoded by BC003067)
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Amount
39 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Molecular weight of GADD34 is 100 kDa confirmed in GADD34 KO mice, and Proteintech's GADD34 antibody 10449-1-AP primarily recognize the 100 kDa band.
Immunogen sequence: SDEEEGEVK ALGAAEKDGE AECPPCIPPP SAFLKAWVYW PGEDTEEEED EEEDEDSDSG SDEEEGEAEA SSSTPATGVF LKSWVYQPGE DTEEEEDEDS DTGSAEDERE AETSASTPPA SAFLKAWVYR PGEDTEEEED EDVDSEDKED DSEAALGEAE SDPHPSHPDQ RAHFRGWGYR PGKETEEEEA AEDWGEAEPC PFRVAIYVPG EKPPPPWAPP RLPLRLQRRL KRPETPTHDP DPETPLKARK VRFSEKVTVH FLAVWAG (307-572 aa encoded by BC003067 )
Target Information
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Growth arrest and DNA damage-inducible protein GADD34; growth arrest and DNA-damage-inducible 34; myeloid differentiation primary response gene 116; Myeloid differentiation primary response protein MyD116; Myeloid differentiation primary response protein MyD116 homolog; PPP1R15A; PR15A; Protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A; unnamed protein product
Gene Aliases: 9630030H21; GADD34; Myd116; PPP1R15A
UniProt ID: (Human) O75807, (Mouse) P17564
Entrez Gene ID: (Human) 23645, (Mouse) 17872
regulation of translation
apoptotic process
positive regulation of gene expression
endoplasmic reticulum unfolded protein response
negative regulation of phosphoprotein phosphatase activity
positive regulation of phosphoprotein phosphatase activity
positive regulation of peptidyl-serine phosphorylation
response to endoplasmic reticulum stress
negative regulation of protein dephosphorylation
regulation of translational initiation by eIF2 alpha dephosphorylation
positive regulation of transcription from RNA polymerase I promoter
regulation of catalytic activity
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
peptidyl-serine dephosphorylation
protein localization to endoplasmic reticulum
positive regulation of peptidyl-serine dephosphorylation
negative regulation of response to endoplasmic reticulum stress
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
regulation of translational initiation
cellular response to DNA damage stimulus
positive regulation of translational initiation in response to stress
regulation of translation in response to endoplasmic reticulum stress
regulation of translational initiation in response to stress
regulation of protein metabolic process
regulation of cell cycle
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
positive regulation of signal transduction by p53 class mediator
negative regulation of PERK-mediated unfolded protein response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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