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Proteintech
GAK Polyclonal Antibody
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Product Details
12147-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GAK Fusion Protein Ag2795 (1-309 aa encoded by BC008668)
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSLLQSALD FLAGPGSLGG ASGRDQSDFV GQTVELGELR LLLASPAPPL SVQSTPRGGP PAAADPFGPL LPSSGNNSQP CSNPDLFGEF LNSDSVTVPP SFPSAHSSPP PSCSADFLHL GDLPGEPSKM TASSSNPDLL GGWAAWTETA ASAVAPTPAT EGPLFSPGGQ PAPCGSQASW TKSQNPDPFA DLGDLSSGLQ GSPAGFPPGG FIPKTATTPK GSSSWQTSRP PAQGASWPPQ AKPPPKACTQ PRPNYASNFS VIGAREERGV RAPSFAQKPK VSENDFEDLL SNQGFSSRSD KKGPKTIAEM (1-309 aa encoded by BC008668)
Target Information
GAK serine/threonine kinase or Cyclin-G-associated kinase was originally identified as a protein that is associated with cyclin G. However, neither CDK5 nor GAK kinase activity is activated by cyclin G nor does GAK affect CDK5 kinase activity. GAK seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: auxilin-2; cyclin G-associated kinase; Cyclin-G-associated kinase; DnaJ homolog subfamily C member 26; unnamed protein product
Gene Aliases: D130045N16Rik; DNAJ26; DNAJC26; GAK
UniProt ID: (Human) O14976, (Mouse) Q99KY4, (Rat) P97874
Entrez Gene ID: (Human) 2580, (Mouse) 231580, (Rat) 81659
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
clathrin binding
cyclin binding
protein binding involved in protein folding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
membrane traffic protein
protein folding
receptor-mediated endocytosis
endoplasmic reticulum organization
Golgi organization
negative regulation of neuron projection development
synaptic vesicle uncoating
protein localization to Golgi apparatus
intracellular transport
clathrin coat assembly
clathrin coat disassembly
clathrin-mediated endocytosis
protein localization to plasma membrane
Golgi to lysosome transport
regulation of clathrin coat assembly
protein phosphorylation
cell cycle
epidermal cell differentiation
phosphorylation
intrahepatic bile duct development
cell development
forebrain morphogenesis
establishment of skin barrier
positive regulation of neural precursor cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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