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Abnova
GAK Polyclonal Antibody, MaxPab™
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Product Details
H00002580-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GAK (AAH08668.1, 1 a.a. approximately 416 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL LLASPAPPLS VQSTPRGGPP AAADPFGPLL PSSGNNSQPC SNPDLFGEFL NSDSVTVPPS FPSAHSSPPP SCSADFLHLG DLPGEPSKMT ASSSNPDLLG GWAAWTETAA SAVAPTPATE GPLFSPGGQP APCGSQASWT KSQNPDPFAD LGDLSSGLQG SPAGFPPGGF IPKTATTPKG SSSWQTSRPP AQGASWPPQA KPPPKACTQP RPNYASNFSV IGAREERGVR APSFAQKPKV SENDFEDLLS NQGFSSRSDK KGPKTIAEMR KQDLAKDTDP LKLKLLDWIE GKERNIRALL STLHTVLWDG ESRWTPVGMA DLVAPEQVKK HYRRAVLAVH PDKAAGQPYE QHAKMIFMEL NDAWSEFENQ GSRPLF
Target Information
GAK serine/threonine kinase or Cyclin-G-associated kinase was originally identified as a protein that is associated with cyclin G. However, neither CDK5 nor GAK kinase activity is activated by cyclin G nor does GAK affect CDK5 kinase activity. GAK seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: auxilin-2; Cyclin-G-associated kinase; DnaJ homolog subfamily C member 26
Gene Aliases: DNAJ26; DNAJC26; GAK
UniProt ID: (Human) O14976
Entrez Gene ID: (Human) 2580
protein phosphorylation
receptor-mediated endocytosis
endoplasmic reticulum organization
Golgi organization
cell cycle
negative regulation of neuron projection development
clathrin coat disassembly
clathrin-mediated endocytosis
establishment of protein localization to Golgi
establishment of protein localization to plasma membrane
Golgi to lysosome transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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