Immunogen sequence: ITRNTTPMYR TPEIIDLYSN FPIGEKQDIW ALGCILYLLC FRQHPFEDGA KLRIVNGKYS IPPHDTQYTV FH
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases, whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5.
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Protein Aliases: auxilin-2; Cyclin G-associated kinase; Cyclin-G-associated kinase
Gene Aliases: DNAJ26; DNAJC26; GAK
UniProt ID: (Human) O14976
Entrez Gene ID: (Human) 2580