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GARP Polyclonal Antibody
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Product Details
OSC00174W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the n-terminal region of human GARP conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: GARP.
Target Information
Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. GARPs are characterized by six repeated motifs of: V V E K K N/E E. These repeat motifs help form an alpha-helix structure. The function(s) of GARP have not been fully characterized, but studies have suggested that GARP helps limit cGMP turnover by inhibiting phosphodiesterase activity. To date, there have been two splice variants characterized: GARP1 (full-length GARP) and GARP2 (truncated GARP). GARP also interacts with part of the larger cytoplasmic domain of the beta-subunit of the cyclic GMP-gated channel found in the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cng channel; CNG channel 4; CNG channel beta-1; CNG-4; cyclic nucleotide gated channel beta 1; Cyclic nucleotide-gated cation channel 4; cyclic nucleotide-gated cation channel beta-1; Cyclic nucleotide-gated cation channel gamma; Cyclic nucleotide-gated cation channel modulatory subunit; cyclic nucleotide-gated channel beta subunit 1; Cyclic nucleotide-gated channel beta-1; GARP; Glutamic acid-rich protein; glutamic-acid-rich protein
Gene Aliases: CNCG2; CNCG3L; CNCG4; CNG4; CNGB1; CNGB1B; GAR1; GARP; GARP2; Gm1959; RCNC2; RCNCb; RCNCbeta; RP45
UniProt ID: (Human) Q14028, (Mouse) E1AZ71
Entrez Gene ID: (Human) 1258, (Rat) 83686, (Mouse) 333329
nucleotide binding
intracellular cyclic nucleotide activated cation channel activity
intracellular cAMP activated cation channel activity
intracellular cGMP activated cation channel activity
calcium channel activity
sodium channel activity
protein binding
ligand-gated ion channel activity
cAMP binding
cGMP binding
cyclic nucleotide-gated ion channel activity
macromolecular complex binding
voltage-gated potassium channel activity
ligand-gated ion channel
retina homeostasis
ion transport
cation transport
potassium ion transport
sodium ion transport
calcium ion transport
G-protein coupled receptor signaling pathway
visual perception
phototransduction
sensory perception of smell
positive regulation of gene expression
olfactory nerve maturation
protein localization to organelle
ion transmembrane transport
sodium ion transmembrane transport
photoreceptor cell outer segment organization
photoreceptor cell maintenance
detection of light stimulus involved in visual perception
detection of chemical stimulus involved in sensory perception of smell
regulation of cytosolic calcium ion concentration
membrane depolarization
calcium ion transmembrane transport
cation transmembrane transport
response to odorant
phototransduction, visible light
regulation of membrane potential
protein heterotetramerization
potassium ion transmembrane transport
regulation of ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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