Immunogen sequence: IEFVVVGPEA PLAAGIVGNL RSAGVQCFGP TAEAAQLESS KRFAKEFMDR HGIPTAQWKA FTKPEEACSF ILSADFPALV VKASGLAAGK GVIVAKSKEE ACKAVQEIMQ EKAFGAAGET IVIEELLDGE EVSCLCFTDG KTV
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 87%.
The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
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Protein Aliases: 5'-phosphoribosylglycinamide transformylase; AIR synthase; AIRS; GAR transformylase; GARS; GART; GARTF; glycinamide ribonucleotide formyltransferase; Glycinamide ribonucleotide synthetase; MGC47764; PAIS; PGFT; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylamine--glycine ligase; phosphoribosylaminoimidazole synthetase; Phosphoribosylformylglycinamidine cyclo-ligase; Phosphoribosylglycinamide formyltransferase; Phosphoribosylglycinamide synthetase; PRGS; Trifunctional purine biosynthetic protein adenosine-3
Gene Aliases: AIRS; Gaps; GARS; GART; GARTF; PAIS; PGFT; PRGS