Invitrogen

GAS1 Polyclonal Antibody

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Questions & Answers

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GAS1 Antibody in Immunohistochemistry (Frozen) (IHC (F)) — Immunohistochemical analysis of Gas1 was detected in immersion fixed frozen sections of mouse embryo (13 d.p.c.) using Goat Anti-mouse Gas1 Antigen Affinity-purified Polyclonal Antibody (Product # PA5-47360) at 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB and counterstained with hematoxylin (blue). Specific staining was localized to developing brain.

Product Details

Applications

Tested Dilution

Publications

Western Blot (WB)

0.1 µg/mL

-

Immunohistochemistry (IHC)

5-15 µg/mL

-

ELISA (ELISA)

0.1-0.4 µg/mL (Detection), 0.2-0.8 µg/mL (Capture)

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse Gas1 Leu39-Ser315

Conjugate

Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2608167

Product Specific Information

In sandwich ELISAs, less than 0.1% cross-reactivity with recombinant human Gas1 and recombinant mouse Gas6 is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GAS-1; Growth arrest-specific protein 1

Gene Aliases: AW554192; Gas-1; Gas1

UniProt ID: (Mouse) Q01721

Entrez Gene ID: (Mouse) 14451

positive regulation of mesenchymal cell proliferation cell cycle cell cycle arrest axon guidance positive regulation of cell proliferation regulation of smoothened signaling pathway dorsal/ventral pattern formation negative regulation of protein processing programmed cell death cerebellum morphogenesis dorsal/ventral neural tube patterning negative regulation of cell growth outer ear morphogenesis middle ear morphogenesis odontogenesis embryonic digit morphogenesis camera-type eye development negative regulation of apoptotic process cell fate commitment negative regulation of smoothened signaling pathway positive regulation of smoothened signaling pathway negative regulation of mitotic cell cycle developmental growth eye morphogenesis embryonic morphogenesis embryonic cranial skeleton morphogenesis embryonic skeletal system development positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation palate development regulation of ER to Golgi vesicle-mediated transport negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Process(es)

protein binding