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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 130-400 of human GAS2L1. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.71 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2807869 |
Immunogen sequence: RKNEKSVVLC LLEVARRGAR LGLLAPRLVQ FEQEIERELR AAPPAPNAPA AGEDTTETAP APGTPARGPR MTPSDLRNLD ELVREILGRC TCPDQFPMIK VSEGKYRVGD SSLLIFVRVL RSHVMVRVGG GWDTLEHYLD KHDPCRCSST AHRPPQPRVC TFSPQRVSPT TSPRPASPVP GSERRGSRPE MTPVSLRSTK EGPETPPRPR DQLPPHPRSR RYSGDSDSSA SSAQSGPLGT RSDDTGTGPR RERPSRRLTT GTPASPRRPP A; Positive Samples: A673, 22Rv1; Cellular Location: Cytoplasm, cytoskeleton
The Gas2 protein is thought to play a role in apoptosis by acting as a cell death substrate for caspases. Gas2, a component of the microfilament system, is cleaved by a caspase (caspase-3 or caspase-7) at Asparagine 278 during apoptosis. The cleaved form of Gas2 dramatically induces the re-arrangement of the Actin cytoskeleton and causes potent changes in the shape of the affected cells. Gas2 is a cytoskeleton and peripheral membrane protein that co-localizes with Actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Gas2 is mainly membrane-associated, but when hyperphosphorylated it will accumulate at membrane ruffles, indicating Gas2 involvement in that process. Gar22 (Gas2-related protein on chromosome 22), also designated growth arrest-specific protein 2-like 1 (Gas2-like1), belongs to the Gas2 family and contains one CH (calponinhomo-logy) domain. It is thought to be involved in the cross-linking of microtubules and microfilaments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GAS2-like protein 1; GAS2-related protein on chromosome 22; growth arrest-specific 2 like 1; Growth arrest-specific protein 2-like 1
Gene Aliases: GAR22; GAS2L1
UniProt ID: (Human) Q99501
Entrez Gene ID: (Human) 10634
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