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GATA1 Polyclonal Antibody

GATA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GATA1 Antibody (10917-2-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using (Product # 10917-2-AP) (GATA1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

GATA1 Antibody in Immunoprecipitation (IP)

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Product Details

10917-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GATA1 Fusion Protein Ag1350 (1-316 aa encoded by BC009797)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.34 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEFPGLGSL GTSEPLPQFV DPALVSSTPE SGVFFPSGPE GLDAAASSTA PSTATAAAAA LAYYRDAEAY RHSPVFQVYP LLNCMEGIPG GSPYAGWAYG KTGLYPASTV CPTREDSPPQ AVEDLDGKGS TSFLETLKTE RLSPDLLTLG PALPSSLPVP NSAYGGPDFS STFFSPTGSP LNSAAYSSPK LRGTLPLPPC EARECVNCGA TATPLWRRDR TGHYLCNACG LYHKMNGQNR PLIRPKKRLI VSKRAGTQCT NCQTTTTTLW RRNASGDPVC NACGLYYKLH HQHYCGGSAQ LMRAQSMASR GGVVSFS (1-316 aa encoded by BC009797)

Target Information

Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Xanthotoxin, a novel inducer of platelet formation, promotes thrombocytopoiesis via IL-1R1 and MEK/ERK signaling.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Lai J,Li Y,Ran M,Huang Q,Huang F,Zhu L,Wu Y,Zou W,Xie X,Tang Y,Yang F,Wu A,Ge G,Wu J

Sat Jul 01 00:00:00 UTC 2023

FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome.

Frontiers in immunology

Wang C,Sample KM,Gajendran B,Kapranov P,Liu W,Hu A,Zacksenhaus E,Li Y,Hao X,Ben-David Y

Mon Jul 05 00:00:00 UTC 2021

Proof of Gene Doping in a Mouse Model with a Human Erythropoietin Gene Transferred Using an Adenoviral Vector.

Genes

Sugasawa T,Nakano T,Fujita SI,Matsumoto Y,Ishihara G,Aoki K,Yanazawa K,Ono S,Tamai S,Manevich L,Ueda H,Ishibashi N,Tamai K,Kanki Y,Yoshida Y,Watanabe K,Takemasa T,Kawakami Y,Takekoshi K

Mon Aug 16 00:00:00 UTC 2021

GATA1 promotes colorectal cancer cell proliferation, migration and invasion via activating AKT signaling pathway.

Molecular and cellular biochemistry

Yu J,Liu M,Liu H,Zhou L

Mon Jul 01 00:00:00 UTC 2019

GATA1 promotes colorectal cancer cell proliferation, migration and invasion via activating AKT signaling pathway.

Molecular and cellular biochemistry

Yu J,Liu M,Liu H,Zhou L

Mon Jul 01 00:00:00 UTC 2019

microRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia.

Oncogene

Su R,Dong L,Zou D,Zhao H,Ren Y,Li F,Yi P,Li L,Zhu Y,Ma Y,Wang J,Wang F,Yu J

Thu Nov 17 00:00:00 UTC 2016

microRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia.

Oncogene

Su R,Dong L,Zou D,Zhao H,Ren Y,Li F,Yi P,Li L,Zhu Y,Ma Y,Wang J,Wang F,Yu J

Thu Nov 17 00:00:00 UTC 2016

microRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia.

Oncogene

Su R,Dong L,Zou D,Zhao H,Ren Y,Li F,Yi P,Li L,Zhu Y,Ma Y,Wang J,Wang F,Yu J

Thu Nov 17 00:00:00 UTC 2016

microRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia.

Oncogene

Su R,Dong L,Zou D,Zhao H,Ren Y,Li F,Yi P,Li L,Zhu Y,Ma Y,Wang J,Wang F,Yu J

Thu Nov 17 00:00:00 UTC 2016

The transcription factor GATA1 and the histone methyltransferase SET7 interact to promote VEGF-mediated angiogenesis and tumor growth and predict clinical outcome of breast cancer.

Oncotarget

Zhang Y,Liu J,Lin J,Zhou L,Song Y,Wei B,Luo X,Chen Z,Chen Y,Xiong J,Xu X,Ding L,Ye Q

Tue Mar 01 00:00:00 UTC 2016

The transcription factor GATA1 and the histone methyltransferase SET7 interact to promote VEGF-mediated angiogenesis and tumor growth and predict clinical outcome of breast cancer.

Oncotarget

Zhang Y,Liu J,Lin J,Zhou L,Song Y,Wei B,Luo X,Chen Z,Chen Y,Xiong J,Xu X,Ding L,Ye Q

Tue Mar 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Eryf1; Erythroid transcription factor; erythroid transcription factor 1; GATA binding protein 1 (globin transcription factor 1); GATA-1; GATA-binding factor 1; GATA-binding protein 1; GATA-binding protein 1 (globin transcription factor 1); GF-1; globin transcription factor 1; HGNC:4170; NF-E1 DNA-binding protein; nuclear factor, erythroid 1; transcription factor GATA1

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Gene Aliases: ERYF1; GATA-1; GATA1; GF-1; GF1; NF-E1; NFE1; XLANP; XLTDA; XLTT

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UniProt ID: (Human) P15976, (Mouse) P17679, (Rat) P43429

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Entrez Gene ID: (Human) 2623, (Mouse) 14460, (Rat) 25172

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Function(s)

transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding DNA binding, bending chromatin DNA binding sequence-specific DNA binding C2H2 zinc finger domain binding RNA polymerase II transcription factor activity, sequence-specific DNA binding chromatin binding metal ion binding DNA-binding transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter in utero embryonic development transcription from RNA polymerase II promoter cell-cell signaling heart development blood coagulation negative regulation of cell proliferation male gonad development organ morphogenesis tissue development regulation of glycoprotein biosynthetic process regulation of definitive erythrocyte differentiation regulation of primitive erythrocyte differentiation erythrocyte differentiation megakaryocyte differentiation platelet formation basophil differentiation eosinophil differentiation negative regulation of bone mineralization positive regulation of osteoblast proliferation embryonic hemopoiesis eosinophil fate commitment negative regulation of apoptotic process positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter digestive tract development erythrocyte development homeostasis of number of cells within a tissue positive regulation of peptidyl-tyrosine phosphorylation platelet aggregation transcriptional activation by promoter-enhancer looping dendritic cell differentiation cellular response to thyroid hormone stimulus negative regulation of transcription regulatory region DNA binding negative regulation of extrinsic apoptotic signaling pathway in absence of ligand transcription, DNA-templated regulation of transcription, DNA-templated myeloid cell differentiation cell development organ regeneration Sertoli cell development cellular response to lipopolysaccharide cellular response to cAMP cellular response to follicle-stimulating hormone stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GATA1 Polyclonal Antibody

GATA1 Antibody (10917-2-AP) in IHC (P)

Product Details

10917-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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