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Invitrogen

GATA6 Polyclonal Antibody

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GATA6 Polyclonal Antibody

Product Details

PA5-85601

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human GATA6. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792741

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Pig (100%).

Positive Control: 293T, 293T nuclear extract.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The GATA6 gene encodes a member of the GATA family of zinc-finger transcription factors, which are critical in regulating gene expression during development. GATA6 plays a crucial role in the differentiation and development of multiple tissues, including the heart and gastrointestinal tract, by interacting with other transcriptional regulators through its zinc-finger domains. This gene influences signaling pathways that drive epithelial-to-mesenchymal transitions (EMTs) and immune surveillance, which are essential processes in maintaining tissue homeostasis and countering tumor progression. In the respiratory tract, GATA6 is essential for the differentiation of lung epithelial cells, impacting the expression of WNT7B and surfactant proteins, vital for proper lung function. Furthermore, studies suggest that GATA6 contributes to an immune-enriched phenotype linked to favorable prognostic outcomes in certain cancers, indicating its potential role in mitigating metastatic propensity by enhancing immune response and surveillance against tumorous cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ASD9; AVSD5; GATA-binding factor 6; Transcription factor GATA-6

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Gene Aliases: GATA6

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UniProt ID: (Human) Q92908

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Entrez Gene ID: (Human) 2627

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription coactivator binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding protein kinase binding sequence-specific DNA binding metal ion binding NFAT protein binding RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development liver development sebaceous gland cell differentiation regulation of antimicrobial humoral response outflow tract septum morphogenesis atrioventricular node development sinoatrial node development type B pancreatic cell differentiation pancreatic A cell differentiation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter phospholipid metabolic process endodermal cell fate determination male gonad development response to xenobiotic stimulus anatomical structure morphogenesis gene expression regulation of gene expression cardiac muscle hypertrophy in response to stress cell differentiation epithelial cell differentiation pancreas development response to retinoic acid negative regulation of transforming growth factor beta1 production negative regulation of transforming growth factor beta2 production tube morphogenesis endodermal cell differentiation atrioventricular canal development negative regulation of apoptotic process response to estrogen cell fate commitment positive regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter animal organ development organ formation system development cardiac muscle tissue development stem cell differentiation smooth muscle cell differentiation cardiac muscle cell differentiation cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation heart contraction lung saccule development Clara cell differentiation Type II pneumocyte differentiation intestinal epithelial cell differentiation cardiac vascular smooth muscle cell differentiation G1 to G0 transition involved in cell differentiation response to growth factor cellular response to gonadotropin stimulus cellular response to hypoxia cellular response to BMP stimulus skin epidermis development positive regulation of cardiac muscle myoblast proliferation negative regulation of sebum secreting cell proliferation
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