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Proteintech
GATM Polyclonal Antibody
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Product Details
12801-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GATM Fusion Protein Ag3754 (74-423 aa encoded by BC004141)
Conjugate
Form
Liquid
Concentration
0.67 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PLEEVIVGR AENACVPPFT IEVKANTYEK YWPFYQKQGG HYFPKDHLKK AVAEIEEMCN ILKTEGVTVR RPDPIDWSLK YKTPDFESTG LYSAMPRDIL IVVGNEIIEA PMAWRSRFFE YRAYRSIIKD YFHRGAKWTT APKPTMADEL YNQDYPIHSV EDRHKLAAQG KFVTTEFEPC FDAADFIRAG RDIFAQRSQV TNYLGIEWMR RHLAPDYRVH IISFKDPNPM HIDATFNIIG PGIVLSNPDR PCHQIDLFKK AGWTIITPPT PIIPDDHPLW MSSKWLSMNV LMLDEKRVMV DANEVPIQKM FEKLGITTIK VNIRNANSLG GGFHCWTCDV RRRGTLQSYL D (74-423 aa encoded by BC004141)
Target Information
AGAT, also known as glycine amidinotransferase (L-arginine:glycine amidinotransferase), GATM or transamidinase, is a 423 amino acid protein belonging to the amidinotransferase family. Encoded by a gene that maps to human chromosome 15q21.1, AGAT exists as three alternatively spliced isoforms and consists of a homodimer, with equilibrium between monomeric and dimeric forms favoring a monomer subunit structure. AGAT localizes to mitochondrial inner membranes, peripheral membranes and cytoplasm. Biallelically expressed in placenta and fetal tissues, AGAT is also expressed in brain, heart, liver, lung, salivary gland and skeletal muscle tissue, with high expression in kidney. AGAT is elevated in the myocardium during heart failure and is decreased in inter-uterine growth restriction (IUGR)-associated placenta. AGAT catalyzes biosynthesis of guanidinoacetate, the immediate precursor of creatine, which plays a vital role in energy metabolism in muscle tissues. AGAT defects are associated with arginine:glycine amidinotransferase deficiency, an autosomal recessive disorder characterized by developmental delay or regression, mental retardation, severe disturbance of expressive and cognitive speech and severe depletion of creatine/phosphocreatine in brain. AGAT may be linked to embryonic and central nervous system development and may function in heart failure response by elevating local creatine synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AT; glycine amidinotransferase (L-arginine:glycine amidinotransferase); Glycine amidinotransferase, mitochondrial; L-arginine: glycine amidinotransferase; L-arginine:glycine amidinotransferase; testicular secretory protein Li 19; Transamidinase
Gene Aliases: 1810003P21Rik; AGAT; AI314789; AT; CCDS3; GATM
UniProt ID: (Human) P50440, (Mouse) Q9D964, (Rat) P50442
Entrez Gene ID: (Human) 2628, (Mouse) 67092, (Rat) 81660
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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