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Invitrogen
GATSL2 Polyclonal Antibody
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FIGURE: 1 / 1
GATSL2 Antibody (PA5-98349) in WB
Western Blot analysis of GATSL2 using a GATSL2 Polyclonal antibody (Product # PA5-98349). Positive WB detected in: HL60 whole cell lysate, SH-SY5Y whole cell lysate, Jurkat whole cell lysate, Hela whole cell lysate. All lanes: CASTOR2 antibody at 1:2000. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 37 kDa.
Product Details
PA5-98349
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 2 protein (82-329AA)
Conjugate
Form
Liquid
Concentration
2.71 mg/mL
Amount
271 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cellular arginine sensor for mTORC1 protein 2; cytosolic arginine sensor for mTORC1 subunit 1; Cytosolic arginine sensor for mTORC1 subunit 2; GATL2; GATS protein like 2; GATS protein-like 1; GATS-like protein 1; GATS-like protein 2
Gene Aliases: CASTOR2; GATSL1; GATSL2
UniProt ID: (Human) A6NHX0
Entrez Gene ID: (Human) 729438
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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