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Proteintech
GBA Polyclonal Antibody
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Product Details
27972-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GBA Fusion Protein Ag27388
Conjugate
Form
Liquid
Concentration
367 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acid beta glucosidase; Acid beta-glucosidase; Alglucerase; Beta-GC; Beta-glucocerebrosidase; Beta-glucosylceramidase 1; Cholesterol glucosyltransferase; Cholesteryl-beta-glucosidase; D-glucosyl-N-acylsphingosine glucohydrolase; glucocerebrosidase; glucosidase, beta, acid; glucosylceramidase; Glucosylceramidase beta 1; glucosylceramidase-like protein; Imiglucerase; Lysosomal acid GCase; Lysosomal acid glucosylceramidase; Lysosomal cholesterol glycosyltransferase; Lysosomal galactosylceramidase; lysosomal glucocerebrosidase; Lysosomal glycosylceramidase; SGTase
Gene Aliases: betaGC; GBA; GBA1; GC; GCase; GCB; GLUC
UniProt ID: (Human) P04062, (Mouse) P17439
Entrez Gene ID: (Human) 2629, (Mouse) 14466
carbohydrate metabolic process
glucosylceramide catabolic process
glycosphingolipid metabolic process
cellular response to starvation
response to pH
positive regulation of macroautophagy
regulation of macroautophagy
termination of signal transduction
regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of interleukin-6 production
regulation of water loss via skin
response to testosterone
positive regulation of protein dephosphorylation
negative regulation of MAP kinase activity
skin morphogenesis
response to estrogen
sphingosine biosynthetic process
ceramide biosynthetic process
negative regulation of inflammatory response
response to glucocorticoid
cellular response to tumor necrosis factor
response to thyroid hormone
positive regulation of proteolysis involved in cellular protein catabolic process
lipid metabolic process
sphingolipid metabolic process
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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