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Fabgennix
GBA Polyclonal Antibody
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Product Details
GLCM-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Glucosylceramidase protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acid beta glucosidase; Acid beta-glucosidase; Alglucerase; Beta-GC; Beta-glucocerebrosidase; Beta-glucosylceramidase 1; Cholesterol glucosyltransferase; Cholesteryl-beta-glucosidase; D-glucosyl-N-acylsphingosine glucohydrolase; glucocerebrosidase; glucocerebrosidase precursor (5' end put.); putative; glucosidase, beta, acid; glucosylceramidase; Glucosylceramidase beta 1; glucosylceramidase-like protein; Imiglucerase; Lysosomal acid GCase; Lysosomal acid glucosylceramidase; Lysosomal cholesterol glycosyltransferase; Lysosomal galactosylceramidase; lysosomal glucocerebrosidase; Lysosomal glycosylceramidase; SGTase; unnamed protein product
Gene Aliases: betaGC; GBA; GBA1; GC; GCase; GCB; GLUC
UniProt ID: (Human) P04062, (Mouse) P17439
Entrez Gene ID: (Human) 2629, (Mouse) 14466
galactosylceramidase activity
glucosylceramidase activity
receptor binding
scavenger receptor binding
protein binding
beta-glucosidase activity
transferase activity
transferase activity, transferring glycosyl groups
hydrolase activity
hydrolase activity, acting on glycosyl bonds
glucosyltransferase activity
steryl-beta-glucosidase activity
carbohydrate metabolic process
lipid metabolic process
sphingolipid metabolic process
glucosylceramide catabolic process
metabolic process
response to pH
termination of signal transduction
negative regulation of interleukin-6 production
regulation of water loss via skin
response to testosterone
positive regulation of protein dephosphorylation
negative regulation of MAP kinase activity
skin morphogenesis
response to estrogen
sphingosine biosynthetic process
ceramide biosynthetic process
response to glucocorticoid
cellular response to tumor necrosis factor
response to thyroid hormone
positive regulation of proteolysis involved in cellular protein catabolic process
mitophagy
glucosylceramide metabolic process
autophagy
mitochondrion organization
lysosome organization
central nervous system development
steroid metabolic process
cholesterol metabolic process
determination of adult lifespan
cellular response to starvation
negative regulation of macromolecule metabolic process
microglia differentiation
regulation of macroautophagy
antigen processing and presentation
lipid storage
cerebellar Purkinje cell layer formation
pyramidal neuron differentiation
respiratory electron transport chain
lipid glycosylation
neuron projection development
negative regulation of protein complex assembly
regulation of TOR signaling
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
T cell differentiation in thymus
regulation of protein catabolic process
regulation of membrane potential
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of MAPK cascade
negative regulation of neuron apoptotic process
cell maturation
brain morphogenesis
homeostasis of number of cells
negative regulation of inflammatory response
neurological system process
neuromuscular process
regulation of protein metabolic process
positive regulation of protein metabolic process
negative regulation of protein metabolic process
neuron apoptotic process
establishment of skin barrier
microglial cell proliferation
motor behavior
hematopoietic stem cell proliferation
response to dexamethasone
lymphocyte migration
skin epidermis development
beta-glucoside catabolic process
positive regulation of neuronal action potential
autophagosome organization
positive regulation of type 2 mitophagy
lysosomal protein catabolic process
regulation of lysosomal protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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