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Product Details
25183-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GBF1 Fusion Protein Ag16579 (1510-1859 aa encoded by BC117681)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ASIYSSWAE EQRHLETGGQ KIEADSRTLW AHCWCPLLQG IACLCCDARR QVRMQALTYL QRALLVHDLQ KLDALEWESC FNKVLFPLLT KLLENISPAD VGGMEETRMR ASTLLSKVFL QHLSPLLSLS TFAALWLTIL DFMDKYMHAG SSDLLSEAIP ESLKNMLLVM DTAEIFHSAD ARGGGPSALW EITWERIDCF LPHLRDELFK QTVIQDPMPM EPQGQKPLAS AHLTSAAGDT RTPGHPPPPE IPSELGACDF EKPESPRAAS SSSPGSPVAS SPSRLSPTPD GPPPLAQPPL ILQPLASPLQ VGVPPMTLPI ILNPALIEAT SPVPLLATPR PTDPIPTSEV N (1510-1859 aa encoded by BC117681)
Target Information
This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BFA-resistant GEF 1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
Gene Aliases: ARF1GEF; GBF1; KIAA0248
UniProt ID: (Human) Q92538
Entrez Gene ID: (Human) 8729
cell activation involved in immune response
ER to Golgi vesicle-mediated transport
retrograde vesicle-mediated transport, Golgi to ER
post-Golgi vesicle-mediated transport
Golgi to endosome transport
Golgi organization
regulation of mitotic cell cycle
protein transport
viral process
neutrophil chemotaxis
regulation of ARF protein signal transduction
protein localization to Golgi apparatus
retrograde transport, endosome to Golgi
positive regulation of GTPase activity
COPI coating of Golgi vesicle
establishment of monopolar cell polarity
protein localization to endoplasmic reticulum exit site
Golgi disassembly
endoplasmic reticulum-Golgi intermediate compartment organization
reactive oxygen species biosynthetic process
protein localization to endoplasmic reticulum tubular network
regulation of protein localization to cell surface
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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