Proteintech

GBP2 Polyclonal Antibody

View all (35) GBP2 antibodies

Questions & Answers

Tech Support

Questions & Answers

Tech Support

Antibody Testing Data (11)

GBP2 Antibody in Western Blot (WB)

FIGURE: 1 / 11

GBP2 Antibody (11854-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 11854-1-AP) GBP2 antibody at dilution of 1:1,000 incubated at room temperature for 1.5 hours.

Product Image Gallery

GBP2 Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with (Product # 11854-1-AP) GBP2 antibody at dilution of 1:1,000 incubated at room temperature for 1.5 hours.

GBP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 11854-1-AP (GBP2 Antibody) at dilution of 1:50 (under 40x lens).

GBP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 11854-1-AP (GBP2 Antibody) at dilution of 1:50 (under 10x lens).

GBP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human spleen tissue slide using 11854-1-AP (GBP2 antibody) at dilution of 1:200 (under 40x lens).

GBP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human spleen tissue slide using 11854-1-AP (GBP2 antibody) at dilution of 1:200 (under 10x lens).

GBP2 Antibody in Western Blot (WB) — Human placenta tissue were subjected to SDS PAGE followed by western blot with 11854-1-AP (GBP2 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours.

GBP2 Antibody in Western Blot (WB) — Rat spleen tissue were subjected to SDS PAGE followed by western blot with 11854-1-AP (GBP2 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

GBP2 Antibody in Western Blot (WB) — Human lung tissue were subjected to SDS PAGE followed by western blot with 11854-1-AP (GBP2 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours.

GBP2 Antibody in Western Blot (WB) — A375 cells were subjected to SDS PAGE followed by western blot with 11854-1-AP ( GBP2 Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

GBP2 Antibody in Western Blot (WB) — K-562 cells were subjected to SDS PAGE followed by western blot with 11854-1-AP (GBP2 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

GBP2 Antibody in Western Blot (WB) — PC-3 cells were subjected to SDS PAGE followed by western blot with 11854-1-AP (GBP2 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours.

Product Details

11854-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 28 publications 28 publications

Immunohistochemistry (IHC)

-

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

-

Immunocytochemistry (ICC/IF)

-

View 15 publications 15 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GBP2 Fusion Protein Ag2425 (131-481 aa encoded by BC022272)

Conjugate

Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: MGTINQQAM DQLHYVTELT DRIKANSSPG NNSVDDSADF VSFFPAFVWT LRDFTLELEV DGEPITADDY LELSLKLRKG TDKKSKSFND PRLCIRKFFP KRKCFVFDWP APKKYLAHLE QLKEEELNPD FIEQVAEFCS YILSHSNVKT LSGGIPVNGP RLESLVLTYV NAISSGDLPC MENAVLALAQ IENSAAVEKA IAHYEQQMGQ KVQLPTETLQ ELLDLHRDSE REAIEVFMKN SFKDVDQMFQ RKLGAQLEAR RDDFCKQNSK ASSDCCMALL QDIFGPLEED VKQGTFSKPG GYRLFTQKLQ ELKNKYYQVP RKGIQAKEVL KKYLESKEDV ADALLQTDQS LS (131-481 aa encoded by BC022272)

Target Information

Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Insight into the Neuroprotective Effect of Genistein-3'-Sodium Sulfonate Against Neonatal Hypoxic-Ischaemic Brain Injury in Rats by Bioinformatics.

Molecular neurobiology

Xie T,Shuang L,Liu G,Zhao S,Yuan Z,Cai H,Jiang L,Huang Z

Wed Feb 01 00:00:00 EST 2023

Guanine nucleotide-binding protein 2, GNBP2, accelerates the progression of clear cell renal cell carcinoma via regulation of STAT3 signaling transduction pathway.

Genes & genomics

Cao Q,Ma J,Li W,Hong P,Shen T,Tong M

Sun Jan 01 00:00:00 EST 2023

Guanine nucleotide-binding protein 2, GNBP2, accelerates the progression of clear cell renal cell carcinoma via regulation of STAT3 signaling transduction pathway.

Genes & genomics

Cao Q,Ma J,Li W,Hong P,Shen T,Tong M

Sun Jan 01 00:00:00 EST 2023

Guanine nucleotide-binding protein 2, GNBP2, accelerates the progression of clear cell renal cell carcinoma via regulation of STAT3 signaling transduction pathway.

Genes & genomics

Cao Q,Ma J,Li W,Hong P,Shen T,Tong M

Sun Jan 01 00:00:00 EST 2023

Guanine nucleotide-binding protein 2, GNBP2, accelerates the progression of clear cell renal cell carcinoma via regulation of STAT3 signaling transduction pathway.

Genes & genomics

Cao Q,Ma J,Li W,Hong P,Shen T,Tong M

Sun Jan 01 00:00:00 EST 2023

Guanine nucleotide-binding protein 2, GNBP2, accelerates the progression of clear cell renal cell carcinoma via regulation of STAT3 signaling transduction pathway.

Genes & genomics

Cao Q,Ma J,Li W,Hong P,Shen T,Tong M

Sun Jan 01 00:00:00 EST 2023

Guanine nucleotide-binding protein 2, GNBP2, accelerates the progression of clear cell renal cell carcinoma via regulation of STAT3 signaling transduction pathway.

Genes & genomics

Cao Q,Ma J,Li W,Hong P,Shen T,Tong M

Sun Jan 01 00:00:00 EST 2023

Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression.

mBio

Hashizaki E,Sasai M,Okuzaki D,Nishi T,Kobayashi T,Iwanaga S,Yamamoto M

Tue Feb 28 00:00:00 EST 2023

Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy.

Cancer cell

Li G,Choi JE,Kryczek I,Sun Y,Liao P,Li S,Wei S,Grove S,Vatan L,Nelson R,Schaefer G,Allen SG,Sankar K,Fecher LA,Mendiratta-Lala M,Frankel TL,Qin A,Waninger JJ,Tezel A,Alva A,Lao CD,Ramnath N,Cieslik M,Harms PW,Green MD,Chinnaiyan AM,Zou W

Mon Feb 13 00:00:00 EST 2023

Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype.

eLife

Korcari A,Nichols AEC,Buckley MR,Loiselle AE

Thu Jan 19 00:00:00 EST 2023

GBP2 serves as a novel prognostic biomarker and potential immune microenvironment indicator in renal cell carcinoma.

Molecular carcinogenesis

Tian Y,Wang H,Guan W,Tu X,Zhang X,Sun Y,Qian C,Song X,Peng B,Cui X

Thu Dec 01 00:00:00 EST 2022

GBP2 serves as a novel prognostic biomarker and potential immune microenvironment indicator in renal cell carcinoma.

Molecular carcinogenesis

Tian Y,Wang H,Guan W,Tu X,Zhang X,Sun Y,Qian C,Song X,Peng B,Cui X

Thu Dec 01 00:00:00 EST 2022

Single-cell RNA-seq reveals interferon-induced guanylate-binding proteins are linked with sarcopenia.

Journal of cachexia, sarcopenia and muscle

Peng Z,Zhang R,Kuang X,Yu C,Niu S,Du Y,Lu D,Li S,Teng Z,Lu S

Thu Dec 01 00:00:00 EST 2022

Single-cell RNA-seq reveals interferon-induced guanylate-binding proteins are linked with sarcopenia.

Journal of cachexia, sarcopenia and muscle

Peng Z,Zhang R,Kuang X,Yu C,Niu S,Du Y,Lu D,Li S,Teng Z,Lu S

Thu Dec 01 00:00:00 EST 2022

Single-cell RNA-seq reveals interferon-induced guanylate-binding proteins are linked with sarcopenia.

Journal of cachexia, sarcopenia and muscle

Peng Z,Zhang R,Kuang X,Yu C,Niu S,Du Y,Lu D,Li S,Teng Z,Lu S

Thu Dec 01 00:00:00 EST 2022

Single-cell RNA-seq reveals interferon-induced guanylate-binding proteins are linked with sarcopenia.

Journal of cachexia, sarcopenia and muscle

Peng Z,Zhang R,Kuang X,Yu C,Niu S,Du Y,Lu D,Li S,Teng Z,Lu S

Thu Dec 01 00:00:00 EST 2022

GBP2 acts as a member of the interferon signalling pathway in lupus nephritis.

BMC immunology

Zhang Y,Liao Y,Hang Q,Sun D,Liu Y

Sat Sep 17 00:00:00 EDT 2022

Enrichment of Newly Synthesized Proteins following treatment of C2C12 Myotubes with Endotoxin and Interferon-γ.

Inflammation

Coleman CS,Stanley BA,Lang CH

Wed Jun 01 00:00:00 EDT 2022

GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.

Oncogene

Xu H,Jin J,Chen Y,Wu G,Zhu H,Wang Q,Wang J,Li S,Grigore FN,Ma J,Chen CC,Lan Q,Li M

Fri Jul 01 00:00:00 EDT 2022

GBP2 as a potential prognostic biomarker in pancreatic adenocarcinoma.

PeerJ

Liu B,Huang R,Fu T,He P,Du C,Zhou W,Xu K,Ren T

Sat Apr 23 00:00:00 EDT 2022

Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization.

Life science alliance

Pradipta A,Sasai M,Motani K,Ma JS,Lee Y,Kosako H,Yamamoto M

Thu Jul 01 00:00:00 EDT 2021

Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity.

Frontiers in immunology

Chowdhury D,Gardner JC,Satpati A,Nookala S,Mukundan S,Porollo A,Landero Figueroa JA,Subramanian Vignesh K

Mon Feb 07 00:00:00 EST 2022

LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy.

Nature cell biology

Li G,Kryczek I,Nam J,Li X,Li S,Li J,Wei S,Grove S,Vatan L,Zhou J,Du W,Lin H,Wang T,Subramanian C,Moon JJ,Cieslik M,Cohen M,Zou W

Sat May 01 00:00:00 EDT 2021

Toxoplasma gondii GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence.

Cellular microbiology

Nyonda MA,Hammoudi PM,Ye S,Maire J,Marq JB,Yamamoto M,Soldati-Favre D

Mon Feb 01 00:00:00 EST 2021

Galectin-3 regulates proinflammatory cytokine function and favours Brucella abortus chronic replication in macrophages and mice.

Cellular microbiology

Tana FL,Guimarães ES,Cerqueira DM,Campos PC,Gomes MTR,Marinho FV,Oliveira SC

Fri Oct 01 00:00:00 EDT 2021

Galectin-3 regulates proinflammatory cytokine function and favours Brucella abortus chronic replication in macrophages and mice.

Cellular microbiology

Tana FL,Guimarães ES,Cerqueira DM,Campos PC,Gomes MTR,Marinho FV,Oliveira SC

Fri Oct 01 00:00:00 EDT 2021

Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to Francisella tularensis.

Frontiers in cellular and infection microbiology

Mohammadi N,Lindgren H,Yamamoto M,Martin A,Henry T,Sjöstedt A

Fri Jan 28 00:00:00 EST 2022

Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to Francisella tularensis.

Frontiers in cellular and infection microbiology

Mohammadi N,Lindgren H,Yamamoto M,Martin A,Henry T,Sjöstedt A

Fri Jan 28 00:00:00 EST 2022

cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophages.

Gut microbes

Yu P,Miao Z,Li Y,Bansal R,Peppelenbosch MP,Pan Q

Tue Jan 11 00:00:00 EST 2022

Cross-talk of pyroptosis and tumor immune landscape in lung adenocarcinoma.

Translational lung cancer research

Wang X,Lin W,Liu T,Xu Z,Wang Z,Cao Z,Feng X,Gao Y,He J

Wed Dec 01 00:00:00 EST 2021

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.

PLoS pathogens

Place DE,Briard B,Samir P,Karki R,Bhattacharya A,Guy CS,Peters JL,Frase S,Vogel P,Neale G,Yamamoto M,Kanneganti TD

Sun Mar 01 00:00:00 EST 2020

GBP2 enhances glioblastoma invasion through Stat3/fibronectin pathway.

Oncogene

Yu S,Yu X,Sun L,Zheng Y,Chen L,Xu H,Jin J,Lan Q,Chen CC,Li M

Wed Jul 01 00:00:00 EDT 2020

GBP2 enhances glioblastoma invasion through Stat3/fibronectin pathway.

Oncogene

Yu S,Yu X,Sun L,Zheng Y,Chen L,Xu H,Jin J,Lan Q,Chen CC,Li M

Wed Jul 01 00:00:00 EDT 2020

Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.

The Journal of biological chemistry

Yu P,Li Y,Li Y,Miao Z,Peppelenbosch MP,Pan Q

Fri Jun 05 00:00:00 EDT 2020

Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis.

Nature microbiology

Burke TP,Engström P,Chavez RA,Fonbuena JA,Vance RE,Welch MD

Fri May 01 00:00:00 EDT 2020

Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock.

Frontiers in immunology

Sakaguchi N,Sasai M,Bando H,Lee Y,Pradipta A,Ma JS,Yamamoto M

Mon May 03 00:00:00 EDT 2021

Lipopolysaccharide restricts murine norovirus infection in macrophages mainly through NF-kB and JAK-STAT signaling pathway.

Virology

Yu P,Li Y,Wang Y,Peppelenbosch MP,Pan Q

Wed Jul 01 00:00:00 EDT 2020

Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.

Life science alliance

Lee Y,Yamada H,Pradipta A,Ma JS,Okamoto M,Nagaoka H,Takashima E,Standley DM,Sasai M,Takei K,Yamamoto M

Wed Jan 01 00:00:00 EST 2020

Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.

Life science alliance

Lee Y,Yamada H,Pradipta A,Ma JS,Okamoto M,Nagaoka H,Takashima E,Standley DM,Sasai M,Takei K,Yamamoto M

Wed Jan 01 00:00:00 EST 2020

Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.

Nature microbiology

Briard B,Karki R,Malireddi RKS,Bhattacharya A,Place DE,Mavuluri J,Peters JL,Vogel P,Yamamoto M,Kanneganti TD

Fri Feb 01 00:00:00 EST 2019

Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.

Nature microbiology

Briard B,Karki R,Malireddi RKS,Bhattacharya A,Place DE,Mavuluri J,Peters JL,Vogel P,Yamamoto M,Kanneganti TD

Fri Feb 01 00:00:00 EST 2019

IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.

Cell

Karki R,Lee E,Place D,Samir P,Mavuluri J,Sharma BR,Balakrishnan A,Malireddi RKS,Geiger R,Zhu Q,Neale G,Kanneganti TD

Thu May 03 00:00:00 EDT 2018

IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.

Cell

Karki R,Lee E,Place D,Samir P,Mavuluri J,Sharma BR,Balakrishnan A,Malireddi RKS,Geiger R,Zhu Q,Neale G,Kanneganti TD

Thu May 03 00:00:00 EDT 2018

LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.

The EMBO journal

Santos JC,Dick MS,Lagrange B,Degrandi D,Pfeffer K,Yamamoto M,Meunier E,Pelczar P,Henry T,Broz P

Thu Mar 15 00:00:00 EDT 2018

Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation.

Journal of immunology (Baltimore, Md. : 1950)

Costa Franco MM,Marim F,Guimarães ES,Assis NRG,Cerqueira DM,Alves-Silva J,Harms J,Splitter G,Smith J,Kanneganti TD,de Queiroz NMGP,Gutman D,Barber GN,Oliveira SC

Mon Jan 15 00:00:00 EST 2018

Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation.

Journal of immunology (Baltimore, Md. : 1950)

Costa Franco MM,Marim F,Guimarães ES,Assis NRG,Cerqueira DM,Alves-Silva J,Harms J,Splitter G,Smith J,Kanneganti TD,de Queiroz NMGP,Gutman D,Barber GN,Oliveira SC

Mon Jan 15 00:00:00 EST 2018

Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses.

Cell reports

Liu BC,Sarhan J,Panda A,Muendlein HI,Ilyukha V,Coers J,Yamamoto M,Isberg RR,Poltorak A

Tue Jul 03 00:00:00 EDT 2018

Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses.

Cell reports

Liu BC,Sarhan J,Panda A,Muendlein HI,Ilyukha V,Coers J,Yamamoto M,Isberg RR,Poltorak A

Tue Jul 03 00:00:00 EDT 2018

Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses.

Cell reports

Liu BC,Sarhan J,Panda A,Muendlein HI,Ilyukha V,Coers J,Yamamoto M,Isberg RR,Poltorak A

Tue Jul 03 00:00:00 EDT 2018

Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence.

Nature

Li P,Jiang W,Yu Q,Liu W,Zhou P,Li J,Xu J,Xu B,Wang F,Shao F

Thu Nov 16 00:00:00 EST 2017

Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence.

Nature

Li P,Jiang W,Yu Q,Liu W,Zhou P,Li J,Xu J,Xu B,Wang F,Shao F

Thu Nov 16 00:00:00 EST 2017

Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence.

Nature

Li P,Jiang W,Yu Q,Liu W,Zhou P,Li J,Xu J,Xu B,Wang F,Shao F

Thu Nov 16 00:00:00 EST 2017

Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence.

Nature

Li P,Jiang W,Yu Q,Liu W,Zhou P,Li J,Xu J,Xu B,Wang F,Shao F

Thu Nov 16 00:00:00 EST 2017

IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.

PLoS pathogens

Wallet P,Benaoudia S,Mosnier A,Lagrange B,Martin A,Lindgren H,Golovliov I,Michal F,Basso P,Djebali S,Provost A,Allatif O,Meunier E,Broz P,Yamamoto M,Py BF,Faudry E,Sjöstedt A,Henry T

Sun Oct 01 00:00:00 EDT 2017

IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.

PLoS pathogens

Wallet P,Benaoudia S,Mosnier A,Lagrange B,Martin A,Lindgren H,Golovliov I,Michal F,Basso P,Djebali S,Provost A,Allatif O,Meunier E,Broz P,Yamamoto M,Py BF,Faudry E,Sjöstedt A,Henry T

Sun Oct 01 00:00:00 EDT 2017

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.

Cell

Man SM,Karki R,Sasai M,Place DE,Kesavardhana S,Temirov J,Frase S,Zhu Q,Malireddi RKS,Kuriakose T,Peters JL,Neale G,Brown SA,Yamamoto M,Kanneganti TD

Thu Oct 06 00:00:00 EDT 2016

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.

Cell

Man SM,Karki R,Sasai M,Place DE,Kesavardhana S,Temirov J,Frase S,Zhu Q,Malireddi RKS,Kuriakose T,Peters JL,Neale G,Brown SA,Yamamoto M,Kanneganti TD

Thu Oct 06 00:00:00 EDT 2016

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

Nature immunology

Man SM,Karki R,Malireddi RK,Neale G,Vogel P,Yamamoto M,Lamkanfi M,Kanneganti TD

Fri May 01 00:00:00 EDT 2015

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

Nature immunology

Man SM,Karki R,Malireddi RK,Neale G,Vogel P,Yamamoto M,Lamkanfi M,Kanneganti TD

Fri May 01 00:00:00 EDT 2015

RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

Proceedings of the National Academy of Sciences of the United States of America

Ohshima J,Sasai M,Liu J,Yamashita K,Ma JS,Lee Y,Bando H,Howard JC,Ebisu S,Hayashi M,Takeda K,Standley DM,Frickel EM,Yamamoto M

Tue Aug 18 00:00:00 EDT 2015

RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

Proceedings of the National Academy of Sciences of the United States of America

Ohshima J,Sasai M,Liu J,Yamashita K,Ma JS,Lee Y,Bando H,Howard JC,Ebisu S,Hayashi M,Takeda K,Standley DM,Frickel EM,Yamamoto M

Tue Aug 18 00:00:00 EDT 2015

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

Nature immunology

Meunier E,Wallet P,Dreier RF,Costanzo S,Anton L,Rühl S,Dussurgey S,Dick MS,Kistner A,Rigard M,Degrandi D,Pfeffer K,Yamamoto M,Henry T,Broz P

Fri May 01 00:00:00 EDT 2015

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

Nature immunology

Meunier E,Wallet P,Dreier RF,Costanzo S,Anton L,Rühl S,Dussurgey S,Dick MS,Kistner A,Rigard M,Degrandi D,Pfeffer K,Yamamoto M,Henry T,Broz P

Fri May 01 00:00:00 EDT 2015

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

Nature

Meunier E,Dick MS,Dreier RF,Schürmann N,Kenzelmann Broz D,Warming S,Roose-Girma M,Bumann D,Kayagaki N,Takeda K,Yamamoto M,Broz P

Thu May 15 00:00:00 EDT 2014

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

Nature

Meunier E,Dick MS,Dreier RF,Schürmann N,Kenzelmann Broz D,Warming S,Roose-Girma M,Bumann D,Kayagaki N,Takeda K,Yamamoto M,Broz P

Thu May 15 00:00:00 EDT 2014

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

Nature

Meunier E,Dick MS,Dreier RF,Schürmann N,Kenzelmann Broz D,Warming S,Roose-Girma M,Bumann D,Kayagaki N,Takeda K,Yamamoto M,Broz P

Thu May 15 00:00:00 EDT 2014

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

Nature

Meunier E,Dick MS,Dreier RF,Schürmann N,Kenzelmann Broz D,Warming S,Roose-Girma M,Bumann D,Kayagaki N,Takeda K,Yamamoto M,Broz P

Thu May 15 00:00:00 EDT 2014

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

Nature

Meunier E,Dick MS,Dreier RF,Schürmann N,Kenzelmann Broz D,Warming S,Roose-Girma M,Bumann D,Kayagaki N,Takeda K,Yamamoto M,Broz P

Thu May 15 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: GBP-2; GTP-binding protein 2; Guanine nucleotide-binding protein 2; guanylate binding protein 2, interferon-inducible; guanylate nucleotide binding protein 2; Guanylate-binding protein 1; Guanylate-binding protein 2; Interferon-induced guanylate-binding protein 2; isoprenylated 67 kDa protein; mGBP-2; mGBP2; p67

Gene Aliases: GBP2

UniProt ID: (Human) P32456, (Mouse) Q9Z0E6, (Rat) Q63663

Entrez Gene ID: (Human) 2634, (Mouse) 14469, (Rat) 171164

Molecular Function: heterotrimeric G-protein

immune response interferon-gamma-mediated signaling pathway type I interferon signaling pathway cellular response to interferon-beta defense response to protozoan adhesion of symbiont to host defense response to Gram-positive bacterium cellular response to lipopolysaccharide cellular response to interferon-gamma metabolic process

Process(es)

GTPase activity protein binding GTP binding nucleotide binding