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GCC2 Antibody (PA5-89457) in IHC (P)
Immunohistochemistry analysis of GCC2 in paraffin-embedded human appendix. Samples were incubated with GCC2 Polyclonal antibody (Product # PA5-89457) using a dilution of 1:150 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-89457
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GCC2 (NP_8521181)
Conjugate
Form
Liquid
Concentration
1.98 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805580
Product Specific Information
Immunogen sequence: MEDLVQDGVA SPATPGTGKS KLETLPKEDL IKFAKKQMML IQKAKSRCTE LEKEIEELRS KPVTEGTGDI IKALTERLDA LLLEKAETEQ QCLSLKKENI KMKQEVEDSV TKMGDAHKEL EQSHINYVKE IENLKNELMA VRSKYSEDKA NLQKQLEEAM NTQLELSEQL KFQNNSEDNV KKLQEEIEKI RPGFEEQILY LQKQLDATTD EKKETVTQLQ NIIEANSQHY QKNINSLQEE LLQLKAIHQE EVKELMCQIE ASAKEHEAEI NKLNELKENL VKQCEASEKN IQKKYECELE; Positive Samples: HeLa, LO2, 22Rv1, Raji, SGC-7901, 293T; Cellular Location: Cytoplasm, Golgi apparatus, Peripheral membrane protein, trans-Golgi network membrane
Target Information
The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 185 kDa Golgi coiled-coil protein; CLL-associated antigen KW-11; CTCL tumor antigen se1-1; GCC protein, 185-kD; GCC185; Golgi coiled-coil protein GCC185; GRIP and coiled-coil domain-containing protein 2; Ran-binding protein 2-like 4; RanBP2L4; Renal carcinoma antigen NY-REN-53
Gene Aliases: 0610043A03Rik; 2210420P05Rik; 2600014C01Rik; AW112121; GCC185; GCC2; KIAA0336; mKIAA0336; RANBP2L4; REN53
UniProt ID: (Human) Q8IWJ2, (Mouse) Q9CT45
Entrez Gene ID: (Human) 9648, (Mouse) 70297
protein targeting to Golgi
protein targeting to lysosome
microtubule organizing center organization
protein localization to Golgi apparatus
microtubule anchoring
late endosome to Golgi transport
retrograde transport, endosome to Golgi
Golgi to plasma membrane protein transport
regulation of protein exit from endoplasmic reticulum
recycling endosome to Golgi transport
Golgi ribbon formation
transport
protein transport
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