This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
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Protein Aliases: GKRP; Glucokinase regulator; Glucokinase regulatory protein; hexokinase 4
Gene Aliases: FGQTL5; GCKR; GKRP; GLRE