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Product Details
PA5-30944
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 214 of Human GCKR
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2548418
Product Specific Information
Recommended positive controls: mouse liver.
Predicted reactivity: Mouse (92%), Rat (92%), Dog (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GKRP; glucokinase regulator; Glucokinase regulatory protein; hexokinase 4
Gene Aliases: FGQTL5; GCKR; GKRP
UniProt ID: (Human) Q14397, (Mouse) Q91X44
Entrez Gene ID: (Human) 2646, (Mouse) 231103
Molecular Function:
protein-binding activity modulator
protein import into nucleus, translocation
carbohydrate metabolic process
response to fructose
regulation of glucose transport
negative regulation of glucokinase activity
urate metabolic process
triglyceride homeostasis
cellular glucose homeostasis
positive regulation of glucokinase activity
protein localization to nucleus
negative regulation of catalytic activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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