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Proteintech
GCLM Polyclonal Antibody, CoraLite® Plus 647
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Product Details
CL647-14241
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
654/674 nm
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MGTDSRAAKA LLARARTLHL QTGNLLNWGR LRKKCPSTHS EELHDCIQKT LNEWSSQINP DLVREFPDVL ECTVSHAVEK INPDEREEMK VSAKLFIVES NSSSSTRSAV DMACSVLGVA QLDSVIIASP PIEDGVNLSL EHLQPYWEEL ENLVQSKKIV AIGTSDLDKT QLEQLYQWAQ VKPNSNQVNL ASCCVMPPDL TAFAKQFDIQ LLTHNDPKEL LSEASFQEAL QESIPDIQAH EWVPLWLLRY SVIVKSRGII KSKGYILQAK RRGS
Target Information
Gamma-glutamylcysteine synthetase (gamma-GCS) is the rate limiting enzyme for glutathione (L-gamma-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. Gamma-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic ntioxidants, heat shock, oxidants and cytokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: gamma glutamylcysteine synthetase; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; GCLM; GCS light chain; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory; Glutamate--cysteine ligase modifier subunit; Glutamate--cysteine ligase regulatory subunit; glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD); glutamate-cysteine ligase modifier subunit; glutamate-cysteine ligase modifier subunit delta2 alternative splicing; glutamate-cysteine ligase regulatory protein; GSC light chain; null; unnamed protein product
Gene Aliases: AI649393; GCLM; Gcmc; GLCLR
UniProt ID: (Human) P48507, (Mouse) O09172, (Rat) P48508
Entrez Gene ID: (Human) 2730, (Mouse) 14630, (Rat) 29739
cysteine metabolic process
glutamate metabolic process
glutathione metabolic process
glutathione biosynthetic process
response to oxidative stress
response to nutrient
apoptotic mitochondrial changes
response to xenobiotic stimulus
response to activity
cellular response to hepatocyte growth factor stimulus
hepatic stellate cell activation
negative regulation of neuron apoptotic process
cellular response to fibroblast growth factor stimulus
response to human chorionic gonadotropin
response to nitrosative stress
regulation of mitochondrial depolarization
cellular response to glucose stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to thyroxine stimulus
regulation of blood vessel diameter
cellular response to leukemia inhibitory factor
negative regulation of extrinsic apoptotic signaling pathway
positive regulation of glutamate-cysteine ligase activity
response to drug
regulation of catalytic activity
regulation of blood vessel size
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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