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Invitrogen

GCN5 Polyclonal Antibody

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GCN5 Polyclonal Antibody

Product Details

PA5-30041

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the C-terminus region of human GCN5. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2547515

Product Specific Information

Recommended positive controls: IMR32, NIH-3T3, JC, BCL-1.

Predicted reactivity: Mouse (100%), Rat (100%), Chicken (96%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

SAGA (Spt-Ada-Gen5 histone acetyltransferase complex) is a histoneacetylase complex which has Gcn5p as catalyst subunit and functions overlapping with the fundamental transcription factor TFIID which has Taf1p as catalyst subunit. However, SAGA and TFIID have different allotment and each accomplishes the important role in the transcription for Housekeeping gene group and Stress Responding gene group. Also, SAGA is a gigantic protein complex which is composed of Ada protein group (5 kinds), TBP related protein group (4 kinds), TAF protein group (5 kinds that also pertain to TFIID), and other protein groups (>6 kinds). As its molecular function, there is the chemical modification of histone, or the recruitment by direct interaction of transcription regulating factor on DNA, or the control of transcription starting reaction by TBP. Gcn5p that show histoneacetylase activity is one kind of the above-mentioned Ada protein group, and in the case of budding yeast it is composed of 439 amino acid residues.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; GCN5 general control of amino acid synthesis-like 2; general control of amino acid synthesis 5-like 2; General control of amino acid synthesis protein 5-like 2; general control of amino acid synthesis, yeast homolog-like 2; General control of amino acid synthesis, yeast, homolog-like 2; general control of amino acid synthesis-like 2; hGCN5; Histone acetyltransferase GCN5; Histone acetyltransferase KAT2A; histone acetyltransferase, GCN5 family; Histone glutaryltransferase KAT2A; Histone succinyltransferase KAT2A; hsGCN5; K(lysine) acetyltransferase 2A; KATA2; Lysine acetyltransferase 2A; MmGCN5; PCAF-B/GCN5; STAF97

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Gene Aliases: 1110051E14Rik; AW212720; GCN5; GCN5L2; hGCN5; KAT2A; mmGCN5; PCAF-b

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UniProt ID: (Human) Q92830, (Mouse) Q9JHD2

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Entrez Gene ID: (Human) 2648, (Mouse) 14534

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Function(s)
chromatin binding transcription coactivator activity histone acetyltransferase activity protein binding N-acetyltransferase activity H3 histone acetyltransferase activity acetyltransferase activity transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups protein phosphatase binding histone deacetylase binding histone acetyltransferase activity (H3-K9 specific) histone acetyltransferase activity (H3-K18 specific) histone acetyltransferase activity (H4-K12 specific) peptide-lysine-N-acetyltransferase activity histone succinyltransferase activity peptide glutaryltransferase activity histone glutaryltransferase activity DNA-binding transcription factor binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development somitogenesis positive regulation of cytokine production neural tube closure gluconeogenesis regulation of DNA repair chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nervous system development heart development long-term memory regulation of gene expression internal peptidyl-lysine acetylation telencephalon development metencephalon development midbrain development positive regulation of cell projection organization regulation of protein stability response to nutrient levels multicellular organism growth protein modification process regulation of RNA splicing regulation of regulatory T cell differentiation negative regulation of gluconeogenesis positive regulation of gluconeogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development negative regulation of centriole replication fibroblast proliferation regulation of synaptic plasticity intracellular distribution of mitochondria regulation of T cell activation regulation of cell division regulation of cell cycle limb development regulation of cartilage development regulation of small molecule metabolic process cellular response to tumor necrosis factor peptidyl-lysine glutarylation regulation of bone development cellular response to nerve growth factor stimulus regulation of stem cell population maintenance positive regulation of cardiac muscle cell differentiation transcription, DNA-templated cell proliferation histone acetylation histone deubiquitination positive regulation of histone acetylation positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter histone H3 acetylation histone H4-K12 acetylation histone H3-K14 acetylation cardiac muscle cell differentiation alpha-tubulin acetylation regulation of mitophagy regulation of nucleic acid-templated transcription positive regulation of protein targeting to mitochondrion positive regulation of transcription regulatory region DNA binding
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