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Invitrogen
GCN5 Polyclonal Antibody
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Product Details
PA5-79548
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human KAT2A/GCN5 (75-106aa DPARPGLSQQQRASQRKAQVRGLPRAKKLEKL).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: A431 whole cell, 22RV1 whole cell, COLO320 whole cell.
Target Information
SAGA (Spt-Ada-Gen5 histone acetyltransferase complex) is a histoneacetylase complex which has Gcn5p as catalyst subunit and functions overlapping with the fundamental transcription factor TFIID which has Taf1p as catalyst subunit. However, SAGA and TFIID have different allotment and each accomplishes the important role in the transcription for Housekeeping gene group and Stress Responding gene group. Also, SAGA is a gigantic protein complex which is composed of Ada protein group (5 kinds), TBP related protein group (4 kinds), TAF protein group (5 kinds that also pertain to TFIID), and other protein groups (>6 kinds). As its molecular function, there is the chemical modification of histone, or the recruitment by direct interaction of transcription regulating factor on DNA, or the control of transcription starting reaction by TBP. Gcn5p that show histoneacetylase activity is one kind of the above-mentioned Ada protein group, and in the case of budding yeast it is composed of 439 amino acid residues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; General control of amino acid synthesis protein 5-like 2; General control of amino acid synthesis, yeast, homolog-like 2; hGCN5; Histone acetyltransferase GCN5; Histone acetyltransferase KAT2A; histone acetyltransferase, GCN5 family; Histone glutaryltransferase KAT2A; Histone succinyltransferase KAT2A; hsGCN5; K(lysine) acetyltransferase 2A; KATA2; Lysine acetyltransferase 2A; STAF97
Gene Aliases: GCN5; GCN5L2; hGCN5; KAT2A; PCAF-b
UniProt ID: (Human) Q92830
Entrez Gene ID: (Human) 2648
chromatin binding
transcription coactivator activity
histone acetyltransferase activity
protein binding
N-acetyltransferase activity
H3 histone acetyltransferase activity
acetyltransferase activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
protein phosphatase binding
histone deacetylase binding
histone acetyltransferase activity (H3-K9 specific)
histone acetyltransferase activity (H3-K18 specific)
histone acetyltransferase activity (H4-K12 specific)
peptide-lysine-N-acetyltransferase activity
histone succinyltransferase activity
peptide glutaryltransferase activity
histone glutaryltransferase activity
DNA-binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
somitogenesis
positive regulation of cytokine production
neural tube closure
gluconeogenesis
regulation of DNA repair
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
heart development
long-term memory
regulation of gene expression
internal peptidyl-lysine acetylation
telencephalon development
metencephalon development
midbrain development
positive regulation of cell projection organization
regulation of protein stability
response to nutrient levels
multicellular organism growth
protein modification process
regulation of RNA splicing
regulation of regulatory T cell differentiation
negative regulation of gluconeogenesis
positive regulation of gluconeogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
negative regulation of centriole replication
fibroblast proliferation
regulation of synaptic plasticity
intracellular distribution of mitochondria
regulation of T cell activation
regulation of cell division
regulation of cell cycle
limb development
regulation of cartilage development
regulation of small molecule metabolic process
cellular response to tumor necrosis factor
peptidyl-lysine glutarylation
regulation of bone development
cellular response to nerve growth factor stimulus
regulation of stem cell population maintenance
positive regulation of cardiac muscle cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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