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Proteintech
GDF15 Polyclonal Antibody
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Product Details
27455-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GDF15 Fusion Protein Ag26760 (30-308 aa encoded by BC008962)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LSLAEASRA SFPGPSELHS EDSRFRELRK RYEDLLTRLR ANQSWEDSNT DLVPAPAVRI LTPEVRLGSG GHLHLRISRA ALPEGLPEAS RLHRALFRLS PTASRSWDVT RPLRRQLSLA RPQAPALHLR LSPPPSQSDQ LLAESSSARP QLELHLRPQA ARGRRRARAR NGDHCPLGPG RCCRLHTVRA SLEDLGWADW VLSPREVQVT MCIGACPSQF RAANMHAQIK TSLHRLKPDT VPAPCCVPAS YNPMVLIQKT DTGVSLQTYD DLLAKDCHCI (30-308 aa encoded by BC008962)
Target Information
GDF-15 belongs to the TGF-beta cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GDF-15; Growth/differentiation factor 15; macrophage inhibiting cytokine-1; Macrophage inhibitory cytokine 1; MIC-1; NAG-1; NAG1; non-steroidal anti-inflammatory drug-activated gene-1; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; Placental bone morphogenetic protein; Placental TGF-beta; Prostate differentiation factor; PTGF-beta; TGF-b superfamily cytokine; unnamed protein product
Gene Aliases: GDF-15; GDF15; HG; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB; SBF
UniProt ID: (Human) Q99988, (Mouse) Q9Z0J7
Entrez Gene ID: (Human) 9518, (Mouse) 23886
reduction of food intake in response to dietary excess
negative regulation of leukocyte migration
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
cell-cell signaling
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of appetite
negative regulation of multicellular organism growth
positive regulation of MAPK cascade
positive regulation of fatty acid oxidation
positive regulation of protein kinase B signaling
negative regulation of SMAD protein import into nucleus
negative regulation of growth hormone receptor signaling pathway
cellular response to chemical stress
energy homeostasis
GDF15-GFRAL signaling pathway
response to metformin
positive regulation of myoblast fusion
positive regulation of pathway-restricted SMAD protein phosphorylation
regulation of apoptotic process
regulation of MAPK cascade
cell development
SMAD protein signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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