Proteintech

GDF15 Polyclonal Antibody

GDF15 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GDF15 Antibody (27455-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human placenta tissue slide using 27455-1-AP ( GDF15 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

27455-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 19 publications 19 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GDF15 Fusion Protein Ag26760 (30-308 aa encoded by BC008962)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LSLAEASRA SFPGPSELHS EDSRFRELRK RYEDLLTRLR ANQSWEDSNT DLVPAPAVRI LTPEVRLGSG GHLHLRISRA ALPEGLPEAS RLHRALFRLS PTASRSWDVT RPLRRQLSLA RPQAPALHLR LSPPPSQSDQ LLAESSSARP QLELHLRPQA ARGRRRARAR NGDHCPLGPG RCCRLHTVRA SLEDLGWADW VLSPREVQVT MCIGACPSQF RAANMHAQIK TSLHRLKPDT VPAPCCVPAS YNPMVLIQKT DTGVSLQTYD DLLAKDCHCI (30-308 aa encoded by BC008962)

Target Information

GDF-15 belongs to the TGF-beta cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression.

Experimental & molecular medicine

Zeng F,Li Y,Meng Y,Sun H,He Y,Yin M,Chen X,Deng G

Wed Feb 01 00:00:00 UTC 2023

N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.

Cell death & disease

Wang R,Wen P,Yang G,Feng Y,Mi Y,Wang X,Zhu S,Chen YQ

Tue Jul 19 00:00:00 UTC 2022

GDF15 negatively regulates RGS16 to impair hepatic lipid metabolism in male mice offspring conceived by in vitro fertilization.

American journal of translational research

Liu J,Zhu Y,Zhu D,Shi Y,Lu L,Li W,Li L,Zhou X,Zhang P,Yang H,Li M,Wang B,Sun M

Sat Nov 19 00:00:00 UTC 2022

SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.

Cancer letters

He R,Shi J,Xu D,Yang J,Shen Y,Jiang YS,Tao L,Yang M,Fu X,Yang JY,Liu D,Huo Y,Shen X,Lu P,Niu N,Sun YW,Xue J,Liu W

Sun Jul 10 00:00:00 UTC 2022

SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.

Cancer letters

He R,Shi J,Xu D,Yang J,Shen Y,Jiang YS,Tao L,Yang M,Fu X,Yang JY,Liu D,Huo Y,Shen X,Lu P,Niu N,Sun YW,Xue J,Liu W

Sun Jul 10 00:00:00 UTC 2022

SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.

Cancer letters

He R,Shi J,Xu D,Yang J,Shen Y,Jiang YS,Tao L,Yang M,Fu X,Yang JY,Liu D,Huo Y,Shen X,Lu P,Niu N,Sun YW,Xue J,Liu W

Sun Jul 10 00:00:00 UTC 2022

SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.

Cancer letters

He R,Shi J,Xu D,Yang J,Shen Y,Jiang YS,Tao L,Yang M,Fu X,Yang JY,Liu D,Huo Y,Shen X,Lu P,Niu N,Sun YW,Xue J,Liu W

Sun Jul 10 00:00:00 UTC 2022

Local anesthetic lidocaine-inducible gene, growth differentiation factor-15 suppresses the growth of cancer cell lines.

Scientific reports

Haraguchi-Suzuki K,Kawabata-Iwakawa R,Suzuki T,Suto T,Takazawa T,Saito S

Thu Aug 25 00:00:00 UTC 2022

Local anesthetic lidocaine-inducible gene, growth differentiation factor-15 suppresses the growth of cancer cell lines.

Scientific reports

Haraguchi-Suzuki K,Kawabata-Iwakawa R,Suzuki T,Suto T,Takazawa T,Saito S

Thu Aug 25 00:00:00 UTC 2022

Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.

Oxidative medicine and cellular longevity

Chen J,Cui Z,Wang Y,Lyu L,Feng C,Feng D,Cheng Y,Li Z,Sun S

Thu Mar 24 00:00:00 UTC 2022

Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.

Oxidative medicine and cellular longevity

Chen J,Cui Z,Wang Y,Lyu L,Feng C,Feng D,Cheng Y,Li Z,Sun S

Thu Mar 24 00:00:00 UTC 2022

GDF15 Contributes to Radioresistance by Mediating the EMT and Stemness of Breast Cancer Cells.

International journal of molecular sciences

Zhao X,Liu X,Hu S,Pan Y,Zhang J,Tai G,Shao C

Sun Sep 18 00:00:00 UTC 2022

GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells.

Cancers

Bellio C,Emperador M,Castellano P,Gris-Oliver A,Canals F,Sánchez-Pla A,Zamora E,Arribas J,Saura C,Serra V,Tabernero J,Littlefield BA,Villanueva J

Mon May 23 00:00:00 UTC 2022

Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.

Nature communications

Bernasocchi T,El Tekle G,Bolis M,Mutti A,Vallerga A,Brandt LP,Spriano F,Svinkina T,Zoma M,Ceserani V,Rinaldi A,Janouskova H,Bossi D,Cavalli M,Mosole S,Geiger R,Dong Z,Yang CG,Albino D,Rinaldi A,Schraml P,Linder S,Carbone GM,Alimonti A,Bertoni F,Moch H,Carr SA,Zwart W,Kruithof-de Julio M,Rubin MA,Udeshi ND,Theurillat JP

Tue Feb 02 00:00:00 UTC 2021

Bottom up proteomics identifies neuronal differentiation pathway networks activated by cathepsin inhibition treatment in neuroblastoma cells that are enhanced by concurrent 13-cis retinoic acid treatment.

Journal of proteomics

Halakos EG,Connell AJ,Glazewski L,Wei S,Mason RW

Wed Feb 10 00:00:00 UTC 2021

Uraemic Cardiomyopathy in Different Mouse Models.

Frontiers in medicine

Chen C,Xie C,Wu H,Wu L,Zhu J,Mao H,Xing C

Tue Aug 03 00:00:00 UTC 2021

Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production.

Gastroenterology

Myojin Y,Hikita H,Sugiyama M,Sasaki Y,Fukumoto K,Sakane S,Makino Y,Takemura N,Yamada R,Shigekawa M,Kodama T,Sakamori R,Kobayashi S,Tatsumi T,Suemizu H,Eguchi H,Kokudo N,Mizokami M,Takehara T

Thu Apr 01 00:00:00 UTC 2021

NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15.

Cell death discovery

Guo F,Zhou Y,Guo H,Ren D,Jin X,Wu H

Tue Apr 13 00:00:00 UTC 2021

NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15.

Cell death discovery

Guo F,Zhou Y,Guo H,Ren D,Jin X,Wu H

Tue Apr 13 00:00:00 UTC 2021

Long noncoding RNA SH3PXD2A-AS1 promotes colorectal cancer progression by regulating p53-mediated gene transcription.

International journal of biological sciences

Hou P,Lin T,Meng S,Shi M,Chen F,Jiang T,Li Z,Li M,Chu S,Zheng J,Bai J

Fri Mar 25 00:00:00 UTC 2022

Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.

Antioxidants (Basel, Switzerland)

Wang L,Zhan J,Huang W

Sat Nov 28 00:00:00 UTC 2020

GDF15 knockdown promotes erastin-induced ferroptosis by decreasing SLC7A11 expression.

Biochemical and biophysical research communications

Chen L,Qiao L,Bian Y,Sun X

Thu May 28 00:00:00 UTC 2020

GDF15 induced by compressive force contributes to osteoclast differentiation in human periodontal ligament cells.

Experimental cell research

Li S,Li Q,Zhu Y,Hu W

Sat Feb 01 00:00:00 UTC 2020

Normoxia is not favorable for maintaining stemness of human endothelial progenitor cells.

Stem cell research

Lin Y,Liu B,Deng T,Zhong J,Feng Z,Zeng Q,Huang G,Chen Z

Mon Jul 01 00:00:00 UTC 2019

GDF15 promotes epithelial-to-mesenchymal transition in colorectal [corrected].

Artificial cells, nanomedicine, and biotechnology

Zhang Y,Wang X,Zhang M,Zhang Z,Jiang L,Li L

Wed Jun 05 00:00:00 UTC 2019

GDF15 promotes epithelial-to-mesenchymal transition in colorectal [corrected].

Artificial cells, nanomedicine, and biotechnology

Zhang Y,Wang X,Zhang M,Zhang Z,Jiang L,Li L

Wed Jun 05 00:00:00 UTC 2019

GDF15 promotes epithelial-to-mesenchymal transition in colorectal [corrected].

Artificial cells, nanomedicine, and biotechnology

Zhang Y,Wang X,Zhang M,Zhang Z,Jiang L,Li L

Wed Jun 05 00:00:00 UTC 2019

GDF15 promotes epithelial-to-mesenchymal transition in colorectal [corrected].

Artificial cells, nanomedicine, and biotechnology

Zhang Y,Wang X,Zhang M,Zhang Z,Jiang L,Li L

Wed Jun 05 00:00:00 UTC 2019

Growth differentiation factor 15 promotes cell viability, invasion, migration, and angiogenesis in human liver carcinoma cell line HepG2.

Clinics and research in hepatology and gastroenterology

Wang L,Liu Y,Li W,Song Z

Fri Sep 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: GDF-15; Growth/differentiation factor 15; macrophage inhibiting cytokine-1; Macrophage inhibitory cytokine 1; MIC-1; NAG-1; NAG1; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; Placental bone morphogenetic protein; Placental TGF-beta; Prostate differentiation factor; PTGF-beta

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Gene Aliases: GDF-15; GDF15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB; SBF

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UniProt ID: (Human) Q99988, (Mouse) Q9Z0J7

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Entrez Gene ID: (Human) 9518, (Mouse) 23886

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Function(s)

cytokine activity transforming growth factor beta receptor binding growth factor activity growth factor

Process(es)

signal transduction transforming growth factor beta receptor signaling pathway cell-cell signaling positive regulation of pathway-restricted SMAD protein phosphorylation regulation of apoptotic process regulation of MAPK cascade cell development SMAD protein signal transduction positive regulation of myoblast fusion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GDF15 Polyclonal Antibody

GDF15 Antibody (27455-1-AP) in IHC (P)

Product Details

27455-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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