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Invitrogen
GDF5 Polyclonal Antibody
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Product Details
PA5-29775
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human GDF5. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Amount
65 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: IMR32.
Predicted reactivity: Human (99%), Mouse (96%), Pig (98%), Rabbit (98%), Chicken (83%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP-14; Bone morphogenetic protein 14; Cartilage-derived morphogenetic protein 1; cartilage-derived morphogenetic protein-1; CDMP-1; GDF-5; Growth/differentiation factor 5; H-GDF-5; LAP-4; Lipopolysaccharide-associated protein 4; LPS-associated protein 4; Radotermin
Gene Aliases: BDA1C; BMP-14; BMP14; CDMP1; DUPANS; GDF5; LAP-4; LAP4; OS5; SYM1B; SYNS2
UniProt ID: (Human) P43026
Entrez Gene ID: (Human) 8200
chondrocyte differentiation
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
cell-cell signaling
response to mechanical stimulus
cell differentiation
embryonic limb morphogenesis
BMP signaling pathway
positive regulation of BMP signaling pathway
negative regulation of chondrocyte differentiation
positive regulation of chondrocyte differentiation
forelimb morphogenesis
hindlimb morphogenesis
regulation of multicellular organism growth
negative regulation of neuron apoptotic process
ossification involved in bone remodeling
positive regulation of neuron differentiation
negative regulation of epithelial cell proliferation
cartilage development
positive regulation of SMAD protein import into nucleus
chondroblast differentiation
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
mesenchymal cell apoptotic process
negative regulation of mesenchymal cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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