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Invitrogen
GDF5 Polyclonal Antibody
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Product Details
PA5-53358
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GDF5. Recombinant protein control fragment (Product #RP-90745).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RYVFDISALE KDGLLGAELR ILRKKPSDTA KPAAPGGGRA AQLKLSSCPS GRQPASLLDV RSVPGLDGSG WEVFDIWKLF RNFKNSAQLC LELEAWERGR AVDL
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
Target Information
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP-14; Bone morphogenetic protein 14; brachypodism; Cartilage-derived morphogenetic protein 1; cartilage-derived morphogenetic protein-1; CDMP-1; GDF-5; growth differentiation factor 5; Growth/differentiation factor 5; H-GDF-5; LAP-4; Lipopolysaccharide-associated protein 4; LPS-associated protein 4; Radotermin
Gene Aliases: BDA1C; BMP-14; BMP14; Bp; brp; Cdmp-1; CDMP1; DUPANS; Gdf-5; GDF5; LAP-4; LAP4; OS5; SYM1B; SYNS2
UniProt ID: (Human) P43026, (Mouse) P43027
Entrez Gene ID: (Human) 8200, (Rat) 252835, (Mouse) 14563
chondrocyte differentiation
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
cell-cell signaling
response to mechanical stimulus
cell differentiation
embryonic limb morphogenesis
BMP signaling pathway
positive regulation of BMP signaling pathway
negative regulation of chondrocyte differentiation
positive regulation of chondrocyte differentiation
forelimb morphogenesis
hindlimb morphogenesis
regulation of multicellular organism growth
negative regulation of neuron apoptotic process
ossification involved in bone remodeling
positive regulation of neuron differentiation
negative regulation of epithelial cell proliferation
cartilage development
positive regulation of SMAD protein import into nucleus
chondroblast differentiation
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
mesenchymal cell apoptotic process
negative regulation of mesenchymal cell apoptotic process
positive regulation of pathway-restricted SMAD protein phosphorylation
growth
regulation of MAPK cascade
SMAD protein signal transduction
SMAD protein import into nucleus
cell development
mitophagy in response to mitochondrial depolarization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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