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|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Recombinant, full length human GDNF protein expressed in E. coli.|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|ELISA (ELISA)||1 µg/ml|
|Inhibition Assays (IA)||2.6 ug/ml|
|Neutralization (Neu)||2.6 ug/ml|
|Western Blot (WB)||2 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-24827 detects GDNF from human samples.
PA1-24827 has been successfully used in neutralization, inhibition assays, and Western blot procedures. Neutralization: The ND50 is 2.6 ug/ml.
The PA1-24827 immunogen is recombinant, full length human GDNF protein expressed in E. coli.
GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
astrocyte-derived trophic factor; Astrocyte-derived trophic factor 1; ATF; ATF1; ATF2; HFB1-GDNF
ATF1; ATF2; GDNF; HFB1-GDNF; HSCR3