Invitrogen

GDNF Polyclonal Antibody

1 Published Figure
2 References
View all (23) GDNF antibodies

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Product Details

PA1-9524

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 2 publications 2 publications

Immunohistochemistry (IHC)

1:50-1:500
-

ELISA (ELISA)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Chicken / IgY

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide mixture based on the human GDNF protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

IgY fraction

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2111385

Product Specific Information

PA1-9524 detects GDNF in human, mouse and rat samples.

PA1-9524 has been successfully used in Western blot, ELISA, and Immunohistochemistry procedures. By Western blot, PA1-9524 detects a 24 kDa protein representing GDNF.

PA1-9524 immunogen is a synthetic peptide based on the human GDNF protein.

Store product at 4°C for up to one week, and -20°C for long term storage.

Target Information

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Astrocyte-derived trophic factor; ATF; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; Glial cell line-derived neurotrophic factor; H-GDNF; hGDNF; mGDNF; neurotrophic factor

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Gene Aliases: AI385739; ATF1; ATF2; GDNF; gndf; HFB1-GDNF; HSCR3

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UniProt ID: (Human) P39905, (Mouse) P48540, (Rat) Q07731

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Entrez Gene ID: (Human) 2668, (Mouse) 14573, (Rat) 25453

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Function(s)
Ras guanyl-nucleotide exchange factor activity receptor binding protein binding growth factor activity protein homodimerization activity transforming growth factor beta receptor binding glial cell-derived neurotrophic factor receptor binding neurotrophic factor
Process(es)
MAPK cascade metanephros development branching involved in ureteric bud morphogenesis neural crest cell migration organ induction postsynaptic membrane organization mesenchymal to epithelial transition involved in metanephros morphogenesis signal transduction nervous system development positive regulation of cell proliferation adult locomotory behavior regulation of gene expression postganglionic parasympathetic fiber development peristalsis neuron projection development positive regulation of monooxygenase activity positive regulation of dopamine secretion negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of cell differentiation positive regulation of transcription from RNA polymerase II promoter mRNA stabilization enteric nervous system development sympathetic nervous system development regulation of dopamine uptake involved in synaptic transmission ureteric bud formation regulation of morphogenesis of a branching structure positive regulation of ureteric bud formation positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis positive regulation of branching involved in ureteric bud morphogenesis regulation of stem cell differentiation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ureteric bud development transmembrane receptor protein tyrosine kinase signaling pathway transforming growth factor beta receptor signaling pathway peripheral nervous system development cell proliferation response to wounding neuron differentiation cellular response to dexamethasone stimulus regulation of ureteric bud formation male gonad development midbrain development retina development in camera-type eye
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