Immunogen sequence: RGQRGKNRGC VLTAIHLNVT DLGLGYETKE ELIFRYCSGS CDAAETTYDK ILKNLSRNRR LVSDKVGQAC CRPIAFDDDL SFLDDNLVYH ILRKHSAKRC GCI; Positive Samples: Mouse brain, Mouse kidney, Rat brain
GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Astrocyte-derived trophic factor; ATF; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; Glial cell line-derived neurotrophic factor; mGDNF; neurotrophic factor
Gene Aliases: AI385739; Gdnf; gndf