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Invitrogen
GDNF Polyclonal Antibody
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Product Details
PA5-89957
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.82 mg/mL
Amount
182 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RGQRGKNRGC VLTAIHLNVT DLGLGYETKE ELIFRYCSGS CDAAETTYDK ILKNLSRNRR LVSDKVGQAC CRPIAFDDDL SFLDDNLVYH ILRKHSAKRC GCI; Positive Samples: Mouse brain, Mouse kidney, Rat brain
Target Information
GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Astrocyte-derived trophic factor; ATF; GDNF; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; Glial cell line-derived neurotrophic factor; H-GDNF; hGDNF; mGDNF; neurotrophic factor
Gene Aliases: AI385739; ATF; ATF1; ATF2; GDNF; gndf; HFB1-GDNF; HSCR3
UniProt ID: (Human) P39905, (Mouse) P48540, (Rat) Q07731
Entrez Gene ID: (Human) 2668, (Mouse) 14573, (Rat) 25453
metanephros development
ureteric bud development
branching involved in ureteric bud morphogenesis
neural crest cell migration
organ induction
postsynaptic membrane organization
mesenchymal to epithelial transition involved in metanephros morphogenesis
signal transduction
nervous system development
peripheral nervous system development
positive regulation of cell proliferation
adult locomotory behavior
tissue development
regulation of gene expression
dorsal spinal cord development
postganglionic parasympathetic fiber development
neuron differentiation
peristalsis
neuron projection development
positive regulation of dopamine secretion
glial cell-derived neurotrophic factor receptor signaling pathway
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
regulation of cell differentiation
positive regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
mRNA stabilization
enteric nervous system development
sympathetic nervous system development
animal organ development
embryonic organ development
regulation of dopamine uptake involved in synaptic transmission
ureteric bud formation
regulation of morphogenesis of a branching structure
chemoattraction of axon
commissural neuron axon guidance
positive regulation of ureteric bud formation
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
regulation of stem cell differentiation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
regulation of semaphorin-plexin signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
cell proliferation
response to wounding
positive regulation of monooxygenase activity
cellular response to dexamethasone stimulus
regulation of ureteric bud formation
male gonad development
midbrain development
retina development in camera-type eye
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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