Lfc is a 118 kDa protein discovered in a screen for oncogenes in NIH 3T3 cells. Lfc is a signaling protein related to Lbc and is part of the Dbl family of proteins. Lfc is a guanine-nucleotide exchange factor (GEF) for the Rho family of small GTPases. Lfc has also been shown to be upstream of the serine-threonine kinase JNK. Lfc has also been shown to mediate the activation of the Rac signaling pathway.
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Protein Aliases: AA408978; GEF-H1; GEFH1; Guanine nucleotide exchange factor H1; LBC'S first cousin; Lbcl1; Lfc; LFP40; Lymphoid blast crisis-like 1; mKIAA0651; Oncogene LFC; Rho guanine nucleotide exchange factor 2; Rhobin
Gene Aliases: AA408978; Arhgef2; GEF; GEF-H1; GEFH1; Kiaa0651; Lbcl1; Lfc; LFP40; mKIAA0651; P40
UniProt ID: (Mouse) Q60875
Entrez Gene ID: (Mouse) 16800