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Invitrogen
GEMC1 Polyclonal Antibody
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Product Details
PA5-21158
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 19 amino acid peptide near the center of human GEMC1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is mouse heart tissue lysate.
PA5-21158 can be used with blocking peptide PEP-1272.
Target Information
The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication. GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein in which the coiled-coil domain is required for the function. GEMC1 binds to the checkpoint and replication factor TopBP1, allowing the binding of GEMC1 to chromatin during pre-replication complex formation. GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication. Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin, suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Geminin coiled-coil domain-containing protein 1
Gene Aliases: GEMC1; Gm1778; Gm606; GMNC
UniProt ID: (Human) A6NCL1, (Mouse) Q3URY2
Entrez Gene ID: (Human) 647309, (Mouse) 239789
DNA replication
spermatogenesis
single fertilization
regulation of DNA-dependent DNA replication initiation
multicellular organism growth
negative regulation of cell cycle
cilium morphogenesis
seminiferous tubule development
cerebrospinal fluid circulation
multi-ciliated epithelial cell differentiation
DNA replication initiation
cell cycle
cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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