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Antibodies Inc
GFAP-R416WT Monoclonal Antibody (N206B/9)
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Product Details
75-279
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N206B/9
Immunogen
Synthetic peptide amino acids 411-422 of human GFAP (accession number P14136).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: KTVEMRDGEV IK
Target Information
GFAP (R416W) refers to a specific mutation in the GFAP gene, where arginine (R) at position 416 is substituted with tryptophan (W). GFAP, or Glial Fibrillary Acidic Protein, is an intermediate filament protein expressed in astrocytes, providing structural support to these glial cells in the central nervous system. The R416W mutation is associated with Alexander disease, a rare neurodegenerative disorder characterized by the accumulation of GFAP aggregates, leading to astrocyte dysfunction and progressive neurological impairment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GFAP; Glial fibrillary acidic protein; glial fibrillary acidic protein alpha; intermediate filament; intermediate filament protein
Gene Aliases: AI836096; ALXDRD; GFAP
UniProt ID: (Human) P14136, (Rat) P47819, (Mouse) P03995
Entrez Gene ID: (Human) 2670, (Rat) 24387, (Mouse) 14580
response to wounding
positive regulation of Schwann cell proliferation
negative regulation of neuron projection development
astrocyte development
extracellular matrix organization
neuron projection regeneration
intermediate filament-based process
intermediate filament organization
regulation of neurotransmitter uptake
Bergmann glial cell differentiation
positive regulation of glial cell proliferation
long-term synaptic potentiation
regulation of protein complex assembly
regulation of chaperone-mediated autophagy
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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