Immunogen sequence: RFHGGNLFFLP GGARSEMMDD LATD
Highest antigen sequence identity to the following orthologs - mouse 64%, rat 60%.
Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen.
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Protein Aliases: Augmenter of liver regeneration; ERV1 homolog; erv1-like growth factor; FAD-linked sulfhydryl oxidase ALR; hepatic regenerative stimulation substance; Hepatopoietin; hepatopoietin protein; hERV1
Gene Aliases: ALR; ERV1; GFER; HERV1; HPO; HPO1; HPO2; HSS
UniProt ID: (Human) P55789
Entrez Gene ID: (Human) 2671