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Invitrogen
GFR alpha-2 Polyclonal Antibody
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FIGURE: 1 / 2
GFR alpha-2 Antibody (PA5-47608) in ICC/IF
Immunocytochemistry analysis of GFR alpha-2 in immersion fixed mouse splenocytes. Samples were incubated in GFR alpha-2 polyclonal antibody (Product # PA5-47608) using a dilution of 5 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to plasma membrane.
Product Details
PA5-47608
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse GFR alpha-2/GDNF R alpha-2 Ser22-Ser441
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human GFR alpha -3 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
GFRa-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GDNF family receptor alpha-2; GDNF re; GDNF receptor alpha-2; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR-alpha 2; GFR-alpha-2; Gfra2; glial cell line derived neurotrophic factor receptor, beta; HpV18gp1; Neurturin receptor alpha; NRTNR-alpha; NTNR-alpha; PI-linked cell-surface accessory protein; RET ligand 2; TGF-beta related neurotrophic factor receptor 2; TRN receptor, GPI-anchored; TGF-beta-related neurotrophic factor receptor 2; TRN receptor, GPI-anchored; unnamed protein product
Gene Aliases: GDNFRB; GFRA2; NRTNR-ALPHA; NTNRA; RETL2; TRNR2
UniProt ID: (Human) O00451, (Mouse) O08842
Entrez Gene ID: (Human) 2675, (Mouse) 14586
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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