This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.
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Protein Aliases: ADP-ribosylation factor-binding protein GGA2; gam; Gamma-adaptin-related protein 2; golgi-associated, gamma adaptin ear containing, ARF binding protein 2; Golgi-localized, gamma ear-containing, ARF-binding protein 2; Vear; VHS domain and ear domain of gamma-adaptin; VHS domain and ear domain-containing protein
Gene Aliases: 1200007E24Rik; GGA2; KIAA1080; mKIAA1080; VEAR