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GHR Polyclonal Antibody
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FIGURE: 1 / 3
GHR Antibody (BS-0654R) in IHC (P)
This image was generously provided by Brandon Menzies, PhD, from The University of Melbourne. Paraffin embedded tammar wallaby (Macropus eugenii) liver labeled with Rabbit Anti-GHR Polyclonal Antibody, Unconjugated (bs-0654R) at 1:300 followed by conjugation to a secondary antibody and staining.
Product Details
BS-0654R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Sheep,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human GHR, amino acids 101-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Growth hormone receptor (GHR) is a gene located on chromosome 5p13.1, encoding a transmembrane receptor that plays a critical role in mediating the effects of growth hormone, which is crucial for growth, metabolism, and tissue development. GHR is expressed in various tissues, including the liver, muscle, and adipose tissue, and facilitates the growth hormone signaling pathway by binding to growth hormone, leading to receptor dimerization and activation of intracellular signaling cascades such as the JAK2-STAT5 pathway. This signaling promotes growth and anabolic processes, influencing body composition, insulin sensitivity, and lipid metabolism. Mutations or alterations in the GHR gene can lead to growth disorders like Laron syndrome, characterized by insensitivity to growth hormone. Understanding GHR's structure and function is pivotal for developing therapeutic strategies for growth deficiencies and metabolic syndromes, as modifying GHR signaling pathways can offer potential interventions in related conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GH receptor; growth hormone binding protein; Growth hormone receptor; Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein); growth hormone receptor precursor splice variant D56; growth hormone receptor protein; growth hormone receptor variant d5-6; growth hormone receptor/binding protein; MGC124963; MGC156665; mutant growth hormone receptor; serum binding protein; Somatotropin receptor; unnamed protein product
Gene Aliases: GHBP; GHIP; GHR; GHR/BP
UniProt ID: (Human) P10912, (Sheep) Q28575, (Rat) P16310, (Mouse) P16882
Entrez Gene ID: (Human) 2690, (Sheep) 443333, (Pig) 397488, (Rat) 25235, (Mouse) 14600
cytokine receptor activity
growth hormone receptor activity
protein binding
lipid binding
peptide hormone binding
growth factor binding
protein kinase binding
protein phosphatase binding
cytokine binding
protein tyrosine kinase activator activity
SH2 domain binding
identical protein binding
protein homodimerization activity
proline-rich region binding
protein tyrosine kinase binding
transmembrane signal receptor
endocytosis
JAK-STAT cascade
positive regulation of cell proliferation
response to gravity
response to hormone
hormone-mediated signaling pathway
cytokine-mediated signaling pathway
taurine metabolic process
receptor internalization
response to food
regulation of response to nutrient levels
response to estradiol
cellular response to insulin stimulus
cellular response to hormone stimulus
response to cytokine
regulation of multicellular organism growth
positive regulation of multicellular organism growth
hormone metabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of MAPK cascade
response to peptide hormone
positive regulation of cell differentiation
positive regulation of JAK-STAT cascade
response to cycloheximide
insulin-like growth factor receptor signaling pathway
response to glucocorticoid
cartilage development involved in endochondral bone morphogenesis
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
negative regulation of growth hormone receptor signaling pathway
response to growth hormone
response to interleukin-1
positive regulation of peptidyl-tyrosine phosphorylation
activation of MAPK activity
allantoin metabolic process
citrate metabolic process
2-oxoglutarate metabolic process
succinate metabolic process
oxaloacetate metabolic process
isoleucine metabolic process
valine metabolic process
creatine metabolic process
fatty acid metabolic process
activation of Janus kinase activity
activation of JAK2 kinase activity
response to morphine
multicellular organism metabolic process
creatinine metabolic process
negative regulation of neuron death
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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