The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
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Protein Aliases: GHRH; GRF; Growth hormone-releasing factor; Growth hormone-releasing hormone; MGC119781; OTTHUMP00000030915; Sermorelin; Somatocrinin; Somatoliberin; Somatorelin
Gene Aliases: GHRF; GHRH; GRF; INN
UniProt ID: (Human) P01286
Entrez Gene ID: (Human) 2691
Molecular Function: neuropeptide